甲状旁腺病灶重量对^99Tc^m-MIBI显像诊断灵敏度的影响  

The influence of parathyroid lesion weight on diagnostic sensitivity of^99Tc^m-MIBI imaging

作　　者：王静 朱玉春 蔡国强 周伟 秦海峰 周青 章斌[3] Wang Jing;Zhu Yuchun;Cai Guoqiang;Zhou Wei;Qin Haifeng;Zhou Qing;Zhang Bin(Department of Nuclear Medicine,the First People's Hospital of Kunshan,Kunshan 215300,China;Department of Pharmacy,the First People's Hospital of Kunshan,Kunshan 215300,China;Department of Nuclear Medicine,the First Affiliated Hospital of Soochow University,Suzhou 215006,China)

机构地区：[1]昆山市第一人民医院核医学科,215300 [2]昆山市第一人民医院药学部,215300 [3]苏州大学附属第一医院核医学科,215006

出　　处：《国际放射医学核医学杂志》2020年第6期352-358,共7页International Journal of Radiation Medicine and Nuclear Medicine

基　　金：2017年昆山市社会发展科技专项(医疗卫生类)(KS1727);2019昆山市重点专科培育项目(昆卫〔2020〕3号)。

摘　　要：目的探讨甲状旁腺病灶重量对^99Tc^m-甲氧基异丁基异腈(MIBI)双时相平面显像及其SPECT/CT早期断层融合显像诊断灵敏度的影响。方法收集2017年2月至2018年10月在昆山市第一人民医院经手术病理学确诊的甲状旁腺功能亢进患者22例,其中男性9例、女性13例,年龄28~73(50.77±8.79)岁。所有患者均于术前行^99Tc^m-MIBI双时相平面显像、^99Tc^m-MIBI SPECT/CT早期断层融合显像,以术后病理学结果为“金标准”。按切除的病灶重量将全部病灶分为两组,A组:病灶重量≤1.00 g,B组:病灶重量>1.00 g。采用χ^2检验分析两种显像方法对不同重量组的诊断效能。结果22例患者中,共切除病灶58个。^99Tc^m-MIBI双时相平面显像对A、B两组的诊断灵敏度分别为47.83%(11/23)和84.00%(21/25),差异有统计学意义(χ^2=7.05,P=0.008);^99Tc^m-MIBI SPECT/CT早期断层融合显像对A、B两组的诊断灵敏度分别为78.26%(18/23)和85.19%(23/27),差异无统计学意义(χ^2=0.40,P=0.525)。^99Tc^m-MIBI SPECT/CT早期断层融合显像对A组的诊断灵敏度高于^99Tc^m-MIBI双时相平面显像,差异有统计学意义(χ^2=4.57,P=0.033)。^99Tc^m-MIBI SPECT/CT早期断层融合显像对B组的诊断灵敏度高于^99Tc^m-MIBI双时相平面显像,但差异无统计学意义(χ^2=0.01,P=0.906)。结论甲状旁腺病灶重量对^99Tc^m-MIBI双时相平面显像诊断灵敏度有影响,当病灶重量较小时,^99Tc^m-MIBI双时相平面显像对其的诊断灵敏度较低;而病灶重量对^99Tc^m-MIBI SPECT/CT早期断层融合显像的诊断灵敏度无明显影响。Objective To investigate the effect of parathyroid lesion weight on the diagnostic sensitivity of ^99Tc^m-MIBI dual-phase plane imaging and ^99Tc^m-MIBI SPECT/CT tomography fusion imaging.Methods A total of 22 patients with hyperparathyroidism that was confirmed via operation and pathology in the First People's Hospital of Kunshan were collected from February 2017 to October 2018.The patients included 9 males and 13 females aged 28–73(50.77±8.79)years old.All patients underwent ^99Tc^m-MIBI biphasic imaging and ^99Tc^m-MIBI SPECT/CT fusion imaging in the early stage.The gold standard was postoperative pathological results.All resected lesions were divided into two groups:group A,wherein lesion weight≤1.00 g,and group B,wherein lesion weight>1.00 g.χ^2 test was used to analyze the diagnostic efficacy of the two imaging methods in the different weight groups.Results A total of 58 lesions were removed from the 22 patients via surgical operation.The diagnostic sensitivity values of ^99Tc^m-MIBI dual-phase plane imaging for groups A and B were 47.83%(11/23)and 84.00%(21/25)respectively,and were statistically significantly different between the two groups(χ^2=7.05,P=0.008).The diagnostic sensitivity values of ^99Tc^m-MIBI SPECT/CT early tomography for groups A and B were 78.26%(18/23)and 85.19%(23/27),respectively,and did not show significant differences between the two groups(χ^2=0.40,P=0.525).In group A,the diagnostic sensitivity of ^99Tc^m-MIBI SPECT/CT early tomography was higher than that of dual-phase plane imaging;this difference was statistically significant(χ^2=4.57,P=0.033).In group B,the diagnostic sensitivity of ^99Tc^m-MIBI SPECT/CT early tomography was higher than that of dual-phase plane imaging;however,no significant difference was observed(χ^2=0.01,P=0.906).Conclusions The weight of parathyroid lesions has an effect on dual-phase planar imaging.Specifically,sensitivity decreased when the parathyroid glands were light.However,lesion weight had no significant effect on the diagnostic sensitivit

关 键 词：99M锝甲氧基异丁基异腈 体层摄影术 发射型计算机 单光子 体层摄影术 X线计算机 甲状旁腺功能亢进症 

分 类 号：R582[医药卫生—内分泌] R817.4[医药卫生—内科学]