动物胆汁酸代谢与肠道微生态的互作关系  

Interaction between Bile Acid Metabolism and Intestinal Micro-Ecology in Animals

作　　者：孔祎頔 李民 王桂芹 KONG Yidi;LI Min;WANG Guiqin(College of Animal Science and Technology,Jilin Agricultural University,Key Laboratory of Ministry of Education of Animal Production and Quality,Jilin Changchun 130118,China)

机构地区：[1]吉林农业大学动物科学技术学院,动物生产及产品质量安全教育部重点实验室,吉林长春130118

出　　处：《中国畜牧杂志》2020年第8期38-44,共7页Chinese Journal of Animal Science

基　　金：国家自然科学基金(31372540);国家现代农业(特色淡水鱼)产业技术体系建设专项资金(CARS-46);吉林省重点科技攻关项目(20170204032NY)。

摘　　要：胆汁酸代谢与肠道微生态密切相关,胆汁酸在肝脏中由胆固醇合成,并通过肠道微生物群进一步代谢,主要存在于肠肝循环中并具有重要调节作用。同时,胆汁酸作为重要的信号分子,其与FXR、FGFR4和TGR5等多种胆汁酸相关受体结合,能有效调节肠道菌群,维持肝肠循环稳态,而肠道菌群的变化直接影响FXR、FGF15等相关基因的表达,进而影响胆汁酸代谢。本文综述了胆汁酸代谢与肠道微生态之间的双向调控机制,进一步明确了二者之间的相互作用关系,为解决动物肝肠胆相关疾病提供科学理论。Bile acid metabolism is closely related to intestinal micro-ecology. Bile acids are synthesized by cholesterol in the liver and further metabolized by the microbiota in the intestine, mainly in the enterohepatic circulation and have important regulatory effects. At the same time, as an important signaling molecule, bile acid binds to various bile acid-related receptors such as FXR, FGFR4 and TGR5, which can effectively regulate intestinal microflora and maintain enterohepatic circulation homeostasis. The changes in intestinal microflora directly affect the expression of related genes such as FXR and FGF15, which in turn affects bile acid metabolism. This paper reviews the bidirectional regulation mechanism between bile acid metabolism and intestinal micro-ecology, and further clarifies the causal relationship between the two, and provides a scientific theory for solving liver and intestinal bile related diseases in animals.

关 键 词：胆汁酸代谢 肝肠循环 胆汁酸受体 肠道菌群 

分 类 号：S816[农业科学—饲料科学]