瞬时感受器电位香草酸亚型1受体及其调节剂对神经病理性疼痛的作用研究进展  

Effects of transient receptor potential vanillic acid subtype 1 receptor and its modulators on neuropathic pain:research advances

作　　者：潘倩 田晓明 尹毅青[1] PAN Qian;TIAN Xiao-ming;YIN Yi-qing(Department of Anesthesiology,China-Japan Friendship Hospital,Beijing 100029,China)

机构地区：[1]中日友好医院手术麻醉科,北京100029

出　　处：《国际药学研究杂志》2020年第6期409-414,共6页Journal of International Pharmaceutical Research

基　　金：中日友好医院企业资助项目(2018-HX-67)。

摘　　要：神经病理性疼痛(NPP)因其发病机制不清,药物治疗效果不佳,一直是困扰医学界的难题。随着分子生物学和电生理技术的发展,发现NPP的复杂病理机制与瞬时感受器电位香草酸亚型1(TRPV1)的激活相关。TRPV1受体主要在周围感觉神经元中表达,可接受外部和内部环境中的有害刺激,并将信息传递到中枢神经系统,从而在周围神经性疼痛中发挥重要作用。研究发现TRPV1调节剂通过阻断TRPV1的痛觉传递功能而发挥镇痛作用,是NPP的潜在治疗药物。本文对TRPV1受体介导的多种NPP模型,以及TRPV1调节剂在NPP治疗中的作用进行综述。Neuropathic pain(NPP)has always been a problem that puzzles the medical community because of its unclear pathogenesis and poor drug treatment.With the development of molecular biology and electrophysiological techniques,studies have shown that the complex pathological mechanism of NPP may be related to the activation of transient receptor potential vanillic acid subtype 1(TRPV1).TRPV1 receptors are mainly expressed in peripheral sensory neurons,which can detect harmful stimuli in the external and internal environment and transmit information to the central nervous system,thereby playing an important role in peripheral neuropathic pain.TRPV1 modulators exert analgesic effects by blocking the pain transmission function of TRPV1 and have become a potential therapeutic agent in the treatment of NPP.This article reviews TRPV1 receptor-mediated NPP models and the role of TRPV1 modulators in NPP treatment.

关 键 词：神经病理性疼痛 瞬时感受器电位香草酸亚型1(TRPV1)受体 TRPV1调节剂 治疗药物 

分 类 号：R349.5[医药卫生—基础医学]