复方甘草酸苷治疗乙型肝炎肝硬化的疗效及对血清IL-17,IL-6,TGF-β和MMP-2水平的影响  

Efficacy of compound glycyrrhizin in the treatment of hepatitis B cirrhosis and its effect on serum levels of IL-17,IL-6,TGF-βand MMP-2

作　　者：袁媛[1] 陈洁[1] 杨雪梅[1] 邓兰[1] YUAN Yuan;CHEN Jie;YANG Xuemei;DENG Lan(Department of Infectious Disease,First Affiliated Hospital of Chengdu Medical College,Chengdu 610500,China)

机构地区：[1]成都医学院第一附属医院感染科,成都610500

出　　处：《临床与病理杂志》2020年第8期2085-2091,共7页Journal of Clinical and Pathological Research

基　　金：四川省医学会感染性肝病(深圳健安)专项科研课题(2017SZJA09)。

摘　　要：目的:研究复方甘草酸苷治疗乙型肝炎肝硬化患者的疗效及对血清IL-17,IL-6,TGF-β和MMP-2水平的影响。方法:选取成都医学院第一附属医院感染科2017年1月至2018年12月期间收治的90例乙型肝炎肝硬化患者分为观察组(n=45)和对照组(n=45)。观察组在对照组治疗的基础上加用复方甘草酸苷,检测生化指标谷丙转氨酶(alanine aminotransfem,ALT)、谷氨酰转肽酶(glutamyltransferase,GGT)、白蛋白(albumin,ALB)、总胆红素(total bilirubin,TBIL)、肝纤维化指标透明质酸(hyaluronic acid,HA)、层黏连蛋白(Laminin,LN)、Ⅳ型胶原(type Ⅳ collagen,Ⅳ-C)和Ⅲ型前胶原(type Ⅲ procollagen,PC-Ⅲ)水平以及细胞因子IL-17,IL-6,TGF-β和MMP-2水平。结果:治疗后,两组ALT,GGT及TBIL水平均显著降低(均P<0.05),观察组ALT,GGT及TBIL均显著低于对照组(均P<0.05)。治疗后,两组患者LN,HA,Ⅳ-C及PC-Ⅲ水平均显著降低(均P<0.05),观察组LN,HA,Ⅳ-C及PC-Ⅲ均显著低于对照组(均P<0.05)。治疗后,两组血清IL-17,IL-6,TGF-β及MMP-2均显著降低(均P<0.05),观察组IL-17,IL-6,TGF-β及MMP-2均显著低于对照组(均P<0.05)。结论:复方甘草酸苷能够改善乙型肝炎肝硬化患者的肝功能,降低血清IL-17,IL-6,TGF-β及MMP-2的水平。Objective:To study the efficacy of compound glycyrrhizin in the treatment of patients with hepatitis B cirrhosis and the effect on serum levels of IL-17,IL-6,TGF-βand MMP-2.Methods:Ninety patients with hepatitis B cirrhosis who were treated between January 2017 and December 2018 in Department of Infectious Diseases of the First Affiliated Hospital of Chengdu Medical College were divided into an observation group(n=45)and a control group(n=45).In the observation group,the compound glycyrrhizin was added on the basis of the treatment of the control group.The levels of the biochemical indicators,including alanine aminotransfem(ALT),glutamyltransferase(GGT),albumin(ALB),total bilirubin(TBIL);the liver fibrosis indicators,hyaluronic acid(HA),Laminin(LN),type Ⅳ collagen(Ⅳ-C)and type Ⅲ procollagen(PC-Ⅲ);and the cytokines,IL-17,IL-6,TGF-β,MMP-2 were detected.Results:After the treatment,the levels of ALT,GGT,and TBIL in the two groups were significantly reduced(P<0.05).After the treatment,the levels of ALT,GGT,and TBIL in the observation group were significantly lower than those in the control group(P<0.05).After treatment,the levels of LN,HA,Ⅳ-C and PC-Ⅲ in the two groups of patients were significantly reduced(P<0.05).In the observation group,LN,HA,Ⅳ-C,and PC-Ⅲ were significantly lower than the control group(P<0.05).After treatment,the serum levels of IL-17,IL-6,TGF-β,and MMP-2 in both groups were significantly reduced(P<0.05).The serum IL-17,IL-6,TGF-β,MMP-2 levels in the observation group were significantly lower than those in the control group(P<0.05).Conclusion:Compound glycyrrhizin can improve the liver function and reduce the levels of IL-17,IL-6,TGF-βand MMP-2 in patients with hepatitis B cirrhosis.

关 键 词：复方甘草酸苷 乙型肝炎肝硬化 IL-17 IL-6 TGF-Β MMP-2 

分 类 号：R512.62[医药卫生—内科学] R575.2[医药卫生—临床医学]