维甲酸类药物的临床应用及对生殖的影响  

Clinical application of retinoids and their effect on reproduction

作　　者：夏晓雪 缪旭[1] 张冬梅 施健[1] XIA Xiao-xue;MIAO Xu;ZHANG Dong-mei;SHI Jian(Department of Dermatology,the Second Affiliated Hospital of Nantong University,Nantong,Jiangsu 226001)

机构地区：[1]南通大学第二附属医院皮肤科,江苏南通226001

出　　处：《皮肤病与性病》2020年第4期498-501,共4页Dermatology and Venereology

基　　金：2019年度南通大学临床医学专项项目(2019LZ003);南通市科技局项目(MSZ18092)。

摘　　要：维甲酸(Retinoic acid,RA)是视黄醇(维生素A)的代谢产物,对痤疮、银屑病、日光性角化、皮肤鳞状细胞癌等皮肤疾病均有治疗作用。但维甲酸有皮肤黏膜干燥、鼻出血、面部红斑、血脂升高、胎儿畸形等副作用,在动物及人类生殖中有"双刃剑"作用。虽然维甲酸类药物外用不会造成畸形,但女性口服维甲酸必须避孕,其对男性生殖影响争议较大。本研究对维甲酸类药物的临床应用及生殖的影响进行综述。Retinoic acid(RA) is derived from retinol(vitamin A) as a metabolic product,which has therapeutic effects on acne, psoriasis, actinic keratosis and skin squamous cell carcinoma. But retinoic acid can cause dryness of skin and mucosa, facial erythema, hyperlipidemia, fetal deformity and so on. Retinoic acid has a double-edged sword in animal and human reproduction. Although topical retinoids generally do not cause abnormalities, women should prevent pregnancy while oral retinoids. The effects on male reproduction are controversial. This article reviews the clinical application of retinoids and their effects on reproduction.

关 键 词：维甲酸 临床应用 副作用 动物实验 男性生殖 女性生殖 

分 类 号：R977.29[医药卫生—药品] R969.3[医药卫生—药学]