氧化苦参碱在防治胰腺纤维化的研究前景及临床应用价值  

Prospect and clinical value of oxymatrine in prevention and treatment of pancreatic fibrosis

作　　者：夏时海 Shi-Hai Xia(Gastroenterology Department of Medical Center of the Chinese People’s Armed Police Force(Institute of Digestive Diseases of Medical Center),Medical Center for Hepatobiliary,Pancreatic and Splenic Disease of the Chinese People’s Armed Police Force,Tianjin Key Laboratory of Hepatopancreatic Fibrosis and Molecular Diagnosis and Treatment,Tianjin 300162,China)

机构地区：[1]武警特色医学中心消化内科(消化疾病研究所),武警部队肝胆胰脾专科中心,天津市肝脏胰腺纤维化与分子诊疗重点实验室,天津市300162

出　　处：《世界华人消化杂志》2020年第17期819-826,共8页World Chinese Journal of Digestology

基　　金：国家自然科学基金资助项目,No.81173393;天津市自然科学基金资助项目,No.17JCYBJC26700;武警特色医学中心创新团队基金资助项目,No.WHTD201310。

摘　　要：研究证实胰腺星状细胞激活是胰腺疾病胰腺纤维化(pancreatic fibrosis,PF)起始与发展的中心环节,但是PF的具体机制尚不清楚,针对PF也无特异性治疗措施.部分基础研究证实中药成分氧化苦参碱(oxymatrine,OMT)对PF有一定的治疗作用,但需要进一步深入研究.可以预见OMT对防治PF具有深远的研究前景和良好的临床应用价值,也有利于更好地开发和利用传统中草药苦参.Studies have confirmed that pancreatic stellate cell activation is the central event in the initiation and development of pancreatic fibrosis(PF),but the specific mechanism of PF is still unknown,and there is no specific treatment for PF.Some basic studies have confirmed that oxymatrine(OMT)has a certain therapeutic effect on PF,but further research is needed.It can be predicted that OMT has a far-reaching research prospect and good clinical application value for the prevention and treatment of PF,and is also conducive to the better development and utilization of traditional Chinese herbal medicine radix sophorae flavescentis.

关 键 词：胰腺星状细胞 胰腺纤维化 氧化苦参碱 

分 类 号：R259[医药卫生—中西医结合]