喹啉杂合体的抗耐药肿瘤活性  

Anti-drug-resistant Cancer Activity of Quinoline Hybrids

作　　者：王丽平[1] 邓桂英 徐沙丽[1] Wang Li-ping;Deng Gui-ying;Xu Sha-li(Liyuan Hospital Affiliated To Tongji Medical College Huazhong University Of Science And Technology,Wuhan 100191)

机构地区：[1]华中科技大学同济医学院附属梨园医院神经内科,武汉100191

出　　处：《国外医药（抗生素分册）》2020年第3期179-184,共6页World Notes on Antibiotics

基　　金：华中科技大学自主创新基金(2012QN051).

摘　　要：喹啉结构片段广泛存在于自然界中,其可供修饰的位点较多,在发现全新结构骨架愈发困难的今天,喹啉已成为各国竞相研究的热点结构单元。喹啉类化合物可通过多种作用机制作用于肿瘤细胞,对包括耐药肿瘤在内的多种肿瘤具有良好的活性。本文综述了喹啉杂合体在抗耐药肿瘤领域的最新研究进展,以期为设计和开发具有高活性的喹啉杂合体指明方向。Quinoline skeleton has caused great interests since its derivatives exist widely in nature,and almost all positions of quinoline moiety can be modified.Quinoline compounds can act on various cancer cells through multiple mechanisms,so quinoline derivatives demonstrated great anticancer activity even against drug-resistant cancer cells.This review emphasizes the recent development of quinoline hybrids with potential anti-drug-resistant cancer activity to indicate the direction for rational design of more effective candidates.

关 键 词：喹啉 杂合体 抗肿瘤 耐药 

分 类 号：R979.1[医药卫生—药品]