454株无乳链球菌感染的临床分布及耐药性分析  

Clinical Distribution and Drug Rsistance Analysis of 454 Strains of Streptococcus agalactiae

作　　者：姜洪文[1] 刘青华[1] 齐文晶 王金文[1] 付宝庆 Jiang Hong-wen;Liu Qing-hua;Qi Wen-jing;Wang Jing-wen;Fu Bao-qing(Daqing Oilfield General Hospital,Daqing 163001;Department of Laboratory Medicine,Xiang'an Hospital of Xiamen University,Xiamen 361102)

机构地区：[1]大庆油田总医院,大庆163001 [2]厦门大学附属翔安医院检验科,厦门361102

出　　处：《国外医药（抗生素分册）》2020年第3期240-242,共3页World Notes on Antibiotics

摘　　要：目的调查大庆油田总医院临床分离的454株无乳链球菌的临床分布及耐药性状况,为临床合理用药提供依据。方法对2016年1月—2018年12月大庆油田总医院分离的454株无乳链球菌进行回顾性分析。结果454株无乳链球菌主要分离自阴道分泌物标本(62.8%)、尿液标本(17.4%)及血液标本(6.6%);患者主要分布于妇科(55.5%)、泌尿外科(11.7%)、产科(8.6%)、肾内科(3.5%)及肛肠科(2.6%);本地区无乳链球菌的耐药率从高到低依次为左氧氟沙星(82.9%)、环丙沙星(82.6%)、克林霉素(76.7%)、四环素(44.5%)及呋喃妥因(8.7%),对青霉素、氨苄西林、万古霉素、利奈唑胺、奎奴普丁/达福普汀及替加环素全部敏感。结论本地区无乳链球菌感染者以非孕妇成人为主,新生儿及产妇仅占9.7%;无乳链球菌主要分离自泌尿生殖系统(80.2%);本地区无乳链球菌对氟喹诺酮类药物及克林霉素耐药严重;青霉素、氨苄西林仍是本地区治疗无乳链球菌感染的首选药物。临床医生应根据药敏试验结果合理使用抗菌药物。Objective To investigate the clinical distribution and drug resistance of 454 strains of Streptococcus agalactiae isolated from the Daqing Oilfield General Hospital,and to provide evidence for clinical rational drug use.Methods The drug susceptibility results of 454 strains of S.agalactiae isolated from Daqing Oilfield General Hospital from January 2016 to February 2018 were retrospectively analyzed.Results 454 strains of S.agalactiae were mainly isolated from vaginal secretion specimens(62.8%),urine specimens(17.4%)and blood specimens(6.6%).The patients were mainly distributed in gynecology(55.5%),urology(11.7%),obstetrics(8.6%),nephrology(3.5%)and anorectal(2.6%).The resistance rates of S.agalactiae in this region from high to low were levofloxacin(82.9%),ciprofloxacin(82.6%),clindamycin(76.7%),tetracycline(44.5%)and nitrofurantoin(8.7%).All S.agalactiae are sensitive to penicillin,ampicillin,vancomycin,linezolid,quinupristin/dalofopin and tigecycline.Conclusion In this region,patients infected with S.agalactiae were predominantly non-pregnant adults.Infected newborns and pregnants only accounted for 9.7%.S.agalactiae was mainly isolated from the genitourinary system(80.2%).The resistance of S.agalactiae to fluoroquinolones and clindamycin was severe in this area.Penicillin and ampicillin were still the first-choice drugs for the treatment of S.agalactiae infection in this area.Clinicians should use antibiotics based on drug susceptibility testing accordingly.

关 键 词：无乳链球菌 临床分布 耐药性 抗菌药物 

分 类 号：R978.5[医药卫生—药品]