补肾益脑方对老年全身麻醉后认知障碍及氧化应激的影响  

Effect of Bushen Yinao Recipe on Cognitive Impairment and Oxidative Stress in Elderly Patients after General Anesthesia

作　　者：王君华[1] 刘蕾 孙自红[1] 刘淑霞[1] 王苗级 WANG Junhua;LIU Lei;SUN Zihong;LIU Shuxia;WANG Miaoji(Luohe Medical College,Luohe 462001,Henan,China;The Third Affiliated Hospital of Luohe Medical College,Luohe 462001,Henan,China;The First Affiliated Hospital of Nanyang Medical College,Nanyang 473000,Henan,China)

机构地区：[1]漯河医学高等专科学校,河南漯河462001 [2]漯河医学高等专科学校第三附属医院,河南漯河462001 [3]南阳医学高等专科学校第一附属医院,河南南阳473000

出　　处：《中华中医药学刊》2020年第8期48-51,共4页Chinese Archives of Traditional Chinese Medicine

基　　金：中华医学会临床医学科研专项基金(17020085326)。

摘　　要：目的探讨补肾益脑方对老年全身麻醉患者认知障碍及氧化应激的影响。方法选择2017年1月-2018年12月在医院手术治疗的老年全麻患者60例为研究对象,随机分为研究组与对照组各30例。两组采用相同的全麻方法。研究组在术前3 d及术后3 d服用中药补肾益脑方剂。比较两组术前及术后MMSE评分、SOD、Ach、MAD水平。结果(1)研究组术后1 d MMSE有所下降,术后3 d恢复至术前水平;对照组术后1 d MMSE显著下降,术后3 d有所恢复,但仍然低于术前水平。术后1 d研究组MMSE显著高于对照组,差异有统计学意义(P<0.05);术后3 d研究组MMSE水平显著高于对照组,差异有统计学意义(P<0.05)。(2)研究组术后1 d SOD有所下降,术后3 d恢复至术前水平;对照组术后1 d SOD显著下降,术后3 d有所恢复,但仍然低于术前水平。术后1 d研究组SOD显著高于对照组,差异有统计学意义(P<0.05);术后3 d研究组SOD水平显著高于对照组,差异有统计学意义(P<0.05)。(3)研究组术后1 d MDA有所升高,术后3 d恢复至术前水平;对照组术后1 d MDA显著升高,术后3 d有所恢复,但仍然高于术前水平。术后1 d研究组MDA显著低于对照组,差异有统计学意义(P<0.05);术后3 d研究组MDA水平显著低于对照组,差异有统计学意义(P<0.05)。(4)研究组术后1 d Ach有所下降,术后3 d恢复至术前水平;对照组术后1 d Ach显著下降,术后3 d有所恢复,但仍然低于术前水平。术后1 d研究组Ach显著高于对照组,差异有统计学意义(P<0.05);术后3 d研究组Ach水平显著高于对照组,差异有统计学意义(P<0.05)。结论补肾益脑方能显著改善老年全麻患者术后认知功能及氧化应激反应。Objective To discuss the effect of Bushen Yinao Recipe on cognitive impairment and oxidative stress in elderly patients after general anesthesia.Methods Sixty elderly patients undergoing general anesthesia from January 2017 to December 2018 were randomly divided into study group and control group with 30 cases in each group.The same general anesthesia method was used in both groups.The study group took Bushen Yinao Recipe three days before operation and three days after operation.The levels of MMSE,SOD,Ach and MAD before and after operation were compared between the two groups.Results(1)MMSE in the study group decreased one day after operation and returned to the preoperative level three days after operation.In the control group,MMSE decreased significantly one day after operation and recovered three days after operation,but was still lower than the preoperative level.The level of MMSE in the study group was significantly higher than that in the control group one day after operation(P<0.05)and the level of MMSE in the study group was significantly higher than that in the control group three days after operation(P<0.05).(2)In the study group,SOD decreased one day after operation and returned to the preoperative level three days after operation,while in the control group,SOD decreased significantly one day after operation and recovered three days after operation,but was still lower than the preoperative level.The SOD level of the study group was significantly higher than that of the control group one day after operation(P<0.05),and the SOD level of the study group was significantly higher than that of the control group three days after operation(P<0.05).(3)The MDA in the study group increased one day after operation and returned to the preoperative level three days after operation.The MDA in the control group increased significantly one day after operation and recovered three days after operation,but was still higher than the preoperative level.The MDA level in the study group was significantly lower than that in t

关 键 词：补肾益脑方 老年 全身麻醉 认知障碍 氧化应激 

分 类 号：R269.142[医药卫生—中西医结合]