生物样品中天麻素测定方法及药代动力学研究进展  

Research Progress on the Determination Methods and Pharmacokinetics of Gastrodin in Biological Samples

作　　者：姜丽[1,2,3] 张启云 涂珺[1,2] 陈雨 王玮玮[1] 李艳 徐国良 Jiang Li;Zhang Qiyun;Tu Jun;Chen Yu;Wang Weiwei;Li Yan;Xu Guoliang(Research Center for Differentiation and Development of TCM Basic Theory,Jiangxi University of Traditional Chinese Medicine,Nanchang 330004,China;Jiangxi Provincial Key Laboratory of TCM Etiopathogenisis,Nanchang 330004,China;Key Laboratory of Pharmacology of Traditional Chinese Medicine in Jiangxi,Nanchang 330004,China)

机构地区：[1]江西中医药大学中医基础理论分化发展研究中心,南昌330004 [2]江西省中医病因生物学重点实验室,南昌330004 [3]江西省中药药理学重点实验室,南昌330004

出　　处：《世界科学技术-中医药现代化》2020年第6期1930-1939,共10页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：国家自然科学基金委员会青年基金项目(81703823):基于药物代谢的参附注射液益气温阳功效相关效应成分研究,负责人:姜丽;江西省科学技术厅自然科学基金项目(20191BAB);基于药物代谢和变量投影重要性分析筛选中药复方功效相关效应成分研究—以参附注射液为例,负责人:姜丽;江西省教育厅项目(GJJ170753):基于VIP技术筛选参附注射液“方随证变”--益气温阳功效相关效应成分研究,负责人:姜丽;江西省卫计委项目(2018B131):基于高分辨质谱联用技术(UPLC-MS-Q-TOF)的参附注射液改善微循环功效相关的物质基础研究,负责人:姜丽;江西省一流学科建设项目(JXSYLXK-ZHYAO120):基于药物代谢思路筛选参附注射液“方随证变”功效相关效应成分及作用机制研究,负责人:姜丽。

摘　　要：天麻素是从兰科植物天麻的块茎中提取分离而得,现已人工合成。天麻素药理作用广泛,如镇痛、镇静安眠、促智、保护神经元、降血压、抗惊厥、抗癫痫、抗氧化、抗衰老、改善微循环等,且安全、无明显毒副作用,其相关制剂在临床上亦被广泛用于心脑血管及神经精神系统疾病,如头痛、冠心病、高血压、后循环缺血性眩晕、突发性耳聋、癫痫、神经衰弱及脑卒中等。考虑到天麻素临床治疗上述疾病常与其他药物或治疗方法联用,故其体内过程及其药代动力学性质不容忽视。目前,有关天麻素综述多集中于药理作用和临床应用方面,而其药代动力学综述鲜见报道。随着天麻素药代动力学研究日渐深入,本研究将从其样品前处理、测定方法、药物ADME过程及影响体内过程的因素等方面较系统全面地对天麻素近年来的药代动力学研究作一综述,以期对天麻素制剂工艺及临床联合配伍应用有所裨益。Gastrodin is extracted from the tubers of the orchidaceae Gastrodia elata BL.and has been artificially synthesized.Gastrodin has sedative,analgesic,neuron protection,hypnotic,anti-convulsion,anti-epilepsy,antioxidation,improve microcirculation and memory,etc.It has low toxicity and less adverse reactions.Its related preparations are widely used in clinic for cardiovascular,cerebrovascular and neuropsychiatric diseases,such as hypertension,coronary heart disease,posterior circulation ischemic vertigo,sudden deafness,headache,neurasthenia,stroke,epilepsy and so on.Considering that gastrodin is often used in combination with other drugs or therapies in the clinical treatment of the above diseases,its disposal process in vivo and pharmacokinetic profile should not be ignored.At present,the reviews on gastrodin mainly focus on pharmacological effects and clinical application,while the pharmacokinetic review is rarely reported.With the deepening of pharmacokinetic study of gastrodin,the pharmacokinetic studies of gastrodin were reviewed systematically and comprehensively in the present paper from the aspects of its sample pretreatment,determination methods,ADME process and the factors affecting the process in vivo,in order to benefit gastrodin preparation technology and clinical application of combined compatibility.

关 键 词：天麻素 生物样品前处理 药代动力学 检测方法 影响因素 

分 类 号：R284[医药卫生—中药学]