基于“脾运化-主肌肉”理论对线粒体脂肪酸氧化与脂质代谢关系的探讨  

Discussion on the Relationship between Mitochondrial Fatty Acid Oxidation and Lipid Metabolism Based on“Spleen Governing Transportation and Transportation and Governing Muscle”

作　　者：吴瑶 陈丝 宋囡[1,2] 王莹[1,2] 吕美君[1,2] 曹媛[1,2] 贾连群[1,2] Wu Yao;Chen Si;Song Nan;Wang Ying;Lv Meiju;Cao Yuan;Jia Lianqun(Key Laboratory of Ministry of Education for TCM Viscera-State Theory and Applications of Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China;Centre for Innovative Engineering Technology in Traditional Chinese Medicine of Liaoning University of Traditional Chinese Medicine,Shenyang 110847,China)

机构地区：[1]辽宁中医药大学中医脏象理论及应用教育部重点实验室,沈阳110847 [2]辽宁中医药大学中医药创新工程技术中心,沈阳110847

出　　处：《世界科学技术-中医药现代化》2020年第6期2024-2028,共5页Modernization of Traditional Chinese Medicine and Materia Medica-World Science and Technology

基　　金：辽宁省中央引导地方科学技术发展专项(2017105002):PMS基于线粒体稳态的冠心病痰瘀病机生物学基础及特色药物创新研究,负责人:杨关林;辽宁省自然科学基金委员会指导计划项目(2019-ZD-0966):PMS绞股蓝总皂苷调控miRNA-210介导线粒体能量代谢防治AS机制研究,负责人:宋囡;辽宁省自然科学基金委员会指导计划项目(20180550767):PMS益气健脾法调控mi RNA干预线粒体能量代谢对Apo E-/-小鼠的影响及机制研究,负责人:王莹。

摘　　要：脾属土,居中焦,为万物生化之母,主运化、主肌肉。脾气健运则气血生化有源,四肢肌肉紧弛有度。线粒体承载着生命活动的物质基础与气血生化之源"脾"功能相类似。线粒体脂肪酸氧化是脂质代谢主要途径之一,也是能量产生的重要方式。线粒体脂肪酸氧化功能正常,则肝脏正常进行物质代谢及能量转化,肌肉运功供能正常。本研究基于脾与线粒体相关性,从"脾运化-主肌肉"探讨线粒体脂肪酸氧化对脂质代谢的影响及机制。The Pi belongs to the earth and is in the Zhong jiao.It is the mother of all things,and it governs transformation,transportation and muscles.If the Pi is healthy,there is sufficient qi and blood,and muscles are strong.The function of mitochondria is similar to that of the Pi.Mitochondrial fatty acid oxidation is one of the main pathways of lipid metabolism and an important way to generate energy.When mitochondrial fatty acid oxidation is normal,the liver normally performs material metabolism and energy conversion,and muscle energy supply is normal.Based on the correlation between the Pi and mitochondria,the effect and mechanism of mitochondrial fatty acid oxidation on lipid metabolism are discussed from"Pi governing transformation,transportation and muscles".

关 键 词：脾主运化 脾主肌肉 线粒体 脂肪酸氧化 

分 类 号：R256.3[医药卫生—中医内科学]