黄果茄中1个新的黄酮类化合物  

A new flavonoid isolated from fruits of Solanum virginianum

作　　者：刁克鹏 李伟 向康林 赵琳 戴胜军[1] DIAO Ke-peng;LI Wei;XIANG Kang-lin;ZHAO Lin;DAI Sheng-jun(School of Pharmaccutical Science,Yantai University,Yantai 264005,China;Administration for MarketRegulation of Longkou City,Longkou 265701,China)

机构地区：[1]烟台大学药学院,山东烟台264005 [2]山东省龙口市市场监督管理局,山东龙口265701

出　　处：《中草药》2020年第15期3845-3849,共5页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(21372189);山东省自然科学基金资助项目(ZR2019HM091)。

摘　　要：目的研究黄果茄Solanum virginianum的化学成分。方法通过硅胶柱色谱、Sephadex LH-20柱色谱及高效制备薄层对黄果茄中的化学成分进行分离纯化,根据理化性质和波谱数据对其化学结构进行阐明。结果从黄果茄中发现并鉴定12个化合物,分别为5-羟基-8-甲氧基-6,7-亚甲二氧基黄酮(1)、7-羟基-6-甲氧基香豆素(2)、秦皮素(3)、5-羟基-6,7,3′,4′-四甲氧基黄酮(4)、5-羟基-4′,6,7-三甲氧基黄酮(5)、二氢阿魏酰酪胺(6)、反式-N-对羟基香豆酰酪胺(7)、5,3′-二羟基-6,7,4′-三甲氧基黄酮(8)、N-[2-(3,4-二羟基苯基)-2-羟乙基]-3-(4-甲氧基苯基)丙-2-烯酰胺(9)、N-反式香豆酰基章鱼胺(10)、5,7,4′-三羟基-6-甲氧基黄酮(11)、5,7,4′-三羟基-8-甲氧基黄酮(12)。结论化合物1为新化合物,命名为黄果茄酮;化合物2~12为首次从黄果茄中分离得到。Objective To study the chemical constituents from the fruits of Solanum virginianum.Methods By means of preparative HPTLC and column chromatography over silica gel and Sephadex LH-20,compounds were isolated and purified.Their structures were elucidated by physico-chemical properties and spectral analyses.Results Twelve compounds were obtained and identified as:5-hydroxy-8-methoxy-6,7-methylenedioxyflavone(1),7-hydroxy-6-methoxy coumarin(2),fraxetin(3),5-hydroxy-6,7,3′,4′-tetramethoxyflavone(4),5-hydroxy-4′,6,7-trimethoxyflavone(5),dihydro-N-feruloyltyramine(6),N-trans-coumaroyltyramine(7),5,3′-dihydroxy-6,7,4′-tritermethoxyflavone(8),N-[2-(3,4-dihydroxyphenyl)-2-hydroxyethyl]-3-(4-methoxyphenyl)-prop-2-enamide(9),N-trans-coumaroyloctopamine(10),5,7,4′-trihydroxy-6-methoxyflavone(11),and 5,7,4′-trihydroxy-8-methoxyflavone(12).Conclusion Compound 1 is a new flavonoid,named as solacarpumon,and compounds 2—12 are isolated from Solanum virginianum for the first time.

关 键 词：黄果茄 7-羟基-6-甲氧基香豆素 秦皮素 5-羟基-6 7 3′ 4′-四甲氧基黄酮 二氢阿魏酰酪胺 黄果茄酮 

分 类 号：R284.1[医药卫生—中药学]