大孔吸附树脂分离纯化中药成分影响因素探讨  

Review on factors influencing separation and purification of Chinese materia medica components by macroporous adsorption resin

作　　者：杨敏[1] 张天锡[1] 史磊[1] 冯帅[1] 李峰[1] YANG Min;ZHANG Tian-xi;SHI Lei;FENG Shuai;LI Feng(Shandong University of Traditional Chinese Medicine,Jinan 250355,China)

机构地区：[1]山东中医药大学,山东济南250355

出　　处：《中草药》2020年第15期4050-4058,共9页Chinese Traditional and Herbal Drugs

基　　金：国家重大新药创制专项(2017ZX09301058)。

摘　　要：大孔吸附树脂具有理化性质稳定、选择性好、吸附能力强且易洗脱、可循环使用且再生处理经济环保、方便制剂成型等优势,近年来广泛应用于天然药物及中药有效成分的精制分离、复方中药制剂的纯化、有害杂质的去除等。通过对大孔吸附树脂的制备、性质、分类、工作原理进行综述,并对其纯化中药成分的影响因素和纯化工艺进行讨论,探究影响大孔吸附树脂纯化中药成分的重要因素,为提高中药成分纯化效果提供参考。In recent years,macroporous adsorption resin has been widely used in the purification and separation of natural medicine and effective components of Chinese materia medica,the purification of compound Chinese medicine preparations,the removal of harmful impurities due to the advantages of stable physical and chemical properties,high selectivity,strong adsorption capacity and easy elution,recyclable use and regeneration treatment,economic and environmental protection,convenient preparation molding and so on.By summarizing the preparation,properties,classification and working principle of macroporous adsorption resin,the influencing factors and purification process of Chinese materia medica components were reviewed.The purpose of this paper is to explore the important factors affecting the purification of Chinese materia medica components by macroporous adsorption resin,and provide reference for improving the purification effect of Chinese materia medica components.

关 键 词：大孔吸附树脂 中药有效成分 制备 性质 分类 工作原理 影响因素 纯化工艺 

分 类 号：R284.2[医药卫生—中药学]