斑蝥炮制沿革及其研究中值得商榷的问题  

Historical evolution in processing and some problems in modern research of Mylabris

作　　者：任艳 刘海波 邓都 莫让瑜[2] 吴发明 REN Yan;LIU Hai-bo;DENG Du;MO Rang-yu;WU Fa-ming(College of Pharmacy,National Institute of Materia Medica,Southwest Minzu University,Chengdu 610041,China;Chongqing Academy of Chinese Materia Medica,Chongqing 400065,China;School of Pharmaceutical Sciences,Zunyi Medical University,Zunyi 563000,China)

机构地区：[1]西南民族大学药学院民族药物研究所,四川成都610041 [2]重庆市中药研究院,重庆400065 [3]遵义医科大学药学院,贵州遵义563000

出　　处：《中草药》2020年第15期4082-4091,共10页Chinese Traditional and Herbal Drugs

基　　金：国家自然科学基金资助项目(81760746);四川省教育厅项目(18ZB0629)。

摘　　要：斑蝥是传统的中药、民族药,在治疗恶性肿瘤、癣症等方面疗效显著,为历版《中国药典》所收载,但斑蝥有大毒,内服需炮制。历代典籍中有关斑蝥炮制方法记载多样,而现代采用的方法主要为净制后再米炒,同时存在各省市炮制规范所规定的工艺与药典规定差异,即"各地各法"现象突出。对斑蝥炮制的历史沿革进行了系统梳理,并对现代研究中斑蝥炮制存在的问题进行了分析与展望,为斑蝥炮制方法及其炮制品质量控制研究提供参考。Mylabris is a traditional Chinese medicine and ethnic medicine,which has significant effects on treatment of malignant tumors and dermatophytosis and so on.It has been recorded in most historical Chinese Pharmacopoeias.However,because of its hypertoxicity in the crud forms,Mylabris needs to be furtherly processed if it is taken orally.There are various methods about how to process it in previous Materia Medica Classics,whereas the most modern approaches are mainly using cleansing technology and stir-baked with rice technology.Moreover,the technologies stipulated by local processing regulations are different from the stipulations of pharmacopoeias.This research combs through the history evolution systematically in the processing of Mylabris,and analyzed the existential issues in modern research on it,so as to provide references for the processing and the quality control of Mylabris.

关 键 词：斑蝥 炮制沿革 去头足翅 米炒工艺 质量控制 

分 类 号：R285[医药卫生—中药学]