石墨烯量子点负载姜黄素与人血清白蛋白作用研究  

Study of the Interaction Between Graphene Quantum Dots Loaded with Curcumin and Human Serum Albumin

作　　者：张秋兰 朱智 洪洋 倪永年 ZHANG Qiulan;ZHU Zhi;HONG Yang;NI Yongnian(College of Chemistry,Nanchang University,Nanchang 330031)

机构地区：[1]南昌大学化学学院,江西南昌330031

出　　处：《分析科学学报》2020年第4期513-517,共5页Journal of Analytical Science

基　　金：国家自然科学基金(No.21665017);中国科学院长春应用化学研究所电分析化学国家重点实验室开放基金(No.SKLEAC201902)。

摘　　要：本文运用紫外-可见光谱、荧光光谱、圆二色谱,结合化学计量学研究石墨烯量子点(GQDs)负载姜黄素(Cur)与人血清白蛋白(HSA)的相互作用。研究表明,Cur通过π-π堆积吸附在GQDs表面并形成复合物。在GQDs存在下,Cur与HSA的结合常数明显增大,作用力主要为氢键。共振光散射实验较好地说明了GQDs、Cur与HSA三者之间复合物的形成。圆二色谱实验证实了GQDs的低毒性,可作为良好的药物载体。本文研究结果对GQDs作为药物载体的应用研究具有一定意义。In this paper,the interaction between human serum albumin and graphene quantum dots(GQDs)loaded with curcumin was studied by UV-Vis,fluorescence spectra,circular dichroism and chemometrics.The study showed that curcumin could form a complex on the surface of GQDs through π-π accumulation.In the presence of GQDs,the binding constant of curcumin and human serum albumin increased and the main force was hydrogen bond.Resonance light scattering experiments showed that GQDs,curcumin and human serum albumin could form a stable complexes.The circular dichroism experiment confirmed the low toxicity of GQDs,which can be used as drug carrier.It is of great significance to the application of graphene quantum dots as drug carriers.

关 键 词：人血清白蛋白 姜黄素 石墨烯量子点 相互作用 

分 类 号：O657.3[理学—分析化学]