恶性疟原虫抗药性分子标记检测方法研究进展  

Advances in methods for detecting drug-resistance molecular markers of Plasmodium falciparum

作　　者：叶升玉 成依依 李曼 周红宁[2] YE Sheng-yu;CHENG Yi-yi;LI Man;ZHOU Hong-ning(Kunming Medical University,Kunming 650500,China;Institute of Parasitic Diseases Control,Yunnan Provincial Key Laboratory of Vector-borne Diseases Control and Research,Yunnan Provincial Center of Malaria Research,Academician Workstation of Professor Jin Ningyi,Pu’er Academician Workstation of Professor Jiang Lubin,Pu’er 665000,China)

机构地区：[1]昆明医科大学,昆明650500 [2]云南省寄生虫病防治所,云南省疟疾研究中心,云南省虫媒传染病防控研究重点实验室,金宁一院士工作站,普洱市江陆斌专家工作站,普洱665000

出　　处：《中国寄生虫学与寄生虫病杂志》2020年第4期490-495,共6页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：国家自然科学基金(No.U1602223);云南省科技重大专项(No.2017ZF007);澜湄合作专项基金(No.2020399)。

摘　　要：疟疾是非洲和东南亚地区流行的重要热带病,严重威胁着当地居民的身体健康。随着恶性疟原虫对抗疟药物抗性的产生与蔓延,全球消除疟疾目标的实现面临着新的挑战。目前恶性疟原虫抗药性监测方法主要包括体内药效试验法、体外药敏检测法和抗性分子标记检测法,其中抗性分子标记检测法被广泛应用。本文就恶性疟原虫抗药性分子标记检测方法研究进展作一综述。Malaria is a major tropical disease prevalent in Africa and Southeast Asia,which seriously threatens the health of local residents.The emergence and spread of Plasmodium falciparum resistance to antimalaria drugs has challenged the realization of global malaria elimination goal.Current monitoring methods for P.falciparum drug resistance mainly include in vivo pharmacodynamic test,in vitro drug sensitivity test,and method of molecular markers of drug-resistance,of which the detection of molecular markers is widely used.This paper reviews research progress in the detection method using molecular markers for drug-resistance of P.falciparum resistance.

关 键 词：恶性疟原虫 抗疟疾药物 分子标记 

分 类 号：R382.31[医药卫生—医学寄生虫学]