低剂量泼尼松联合吗替麦考酚酯治疗IgA肾病的效果分析  

Effects of Low-dose Prednisone Combined with Mycophenolate Mofetil on IgA Nephropathy

作　　者：黄宇静[1] 伍锦泉[1] 黄力[1] 黄佳丽 陈玉平[1] HUANG Yujing;WU Jinquan;HUANG Li;HUANG Jiali;CHEN Yuping(The First People’s Hospital of Zhaoqing,Zhaoqing 526020,China;不详)

机构地区：[1]肇庆市第一人民医院,广东肇庆526020

出　　处：《中外医学研究》2020年第22期15-17,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:分析低剂量泼尼松+吗替麦考酚酯治疗IgA肾病的效果。方法:选取本院2016年7月-2019年7月收治的78例IgA肾病患者,采取随机分组表法分为两组,每组39例。参照组给予低剂量泼尼松+环磷酰胺治疗,试验组给予低剂量泼尼松+吗替麦考酚酯治疗,对比两组临床疗效、肾脏纤维化指标、血清TGF-β1、TNF-α水平及不良反应。结果:试验组临床总有效率(94.87%)明显高于参照组(71.79%),试验组治疗6个月后血清TIMP-1、LN、C-Ⅳ、TGF-β1、TNF-α水平均明显低于参照组,试验组不良反应发生率(5.13%)明显低于参照组(25.64%),差异均有统计学意义(P<0.05)。结论:低剂量泼尼松+吗替麦考酚酯可有效降低IgA肾病患者尿蛋白定量,改善肾功能,抑制TGF-β1、TNF-α高表达状态,且不良反应较少,值得借鉴。Objective:To analyze the effects of Low-dose Prednisone+Mycophenolate Mofetil in patients with IgA nephropathy.Method:A total of 78 patients with IgA nephropathy admitted in our hospital from July 2016 to July 2019 were randomly divided into two groups,39 cases in each group.The reference group was treated with low-dose Prednisone+Cyclophosphamide.The experimental group was treated with low-dose Prednisone+Mycophenolate Mofetil.The clinical efficacy,renal fibrosis index,serum TGF-β1,TNF-αlevels,and adverse reactions were compared between the two groups.Result:The total clinical effective rate(94.87%)in the experimental group was significantly higher than that in the reference group(71.79%);after 6 months of treatment,the serum TIMP-1,LN,C-Ⅳ,TGF-β1,and TNF-αlevels were significantly lower in the experimental group than those in the reference group;and the incidence of adverse reactions in the experimental group(5.13%)was significantly lower than that in the reference group(25.64%);the differences were statistically significant(P<0.05).Conclusion:Low-dose Prednisone+Mycophenolate Mofetil can effectively reduce the urinary protein quantification,improve renal function,and inhibit the high expression of TGF-β1 and TNF-αin patients with IgA nephropathy.

关 键 词：泼尼松 吗替麦考酚酯 IGA肾病 肾纤维化 转化生长因子-Β1 肿瘤坏死因子-α 

分 类 号：R692.31[医药卫生—泌尿科学]