外周神经促进创伤后组织异位矿化的研究进展  

Research Progress of Peripheral Nerve Promoting Heterotopic Ossification of Post-Traumatic Tissues

作　　者：覃文聘 高鹏 牛丽娜 焦凯 QIN Wenpin;GAO Peng;NIU Lina;JIAO Kai(State Key Laboratory of Military Stomatology/National Clinical Research Center for Oral Diseases/Shaanxi Clinical Research Center for Oral Diseases/Department of Mucosal Diseases,School of Stomatology,the Fourth Military Medical University,Xi′an 710032,China)

机构地区：[1]军事口腔医学国家重点实验室,口腔疾病国家临床医学研究中心,陕西省口腔疾病临床医学研究中心,第四军医大学口腔医院黏膜病科,西安710032

出　　处：《医学综述》2020年第17期3381-3385,共5页Medical Recapitulate

基　　金：国家自然科学基金(81671012,81870787);军队青年培育项目(16QNP117)。

摘　　要：组织异位矿化是软组织错误的修复过程,是外科手术和创伤性损伤的常见并发症,发生率高,各种形式的异位矿化是临床亟待解决的一大问题,由于组织异位矿化的发病机制目前尚未完全阐明,故治疗十分困难。外周神经在异位矿化的发生与发展中发挥了举足轻重的致病作用,主要通过神经炎症诱导血管神经屏障开放、神经干细胞迁移至骨沉积部位并分化为成骨细胞、外周神经调控棕色脂肪组织促进软骨成骨和新血管生成三个方面影响异位矿化的发生。未来,如何将调控外周神经活性运用于治疗组织异位矿化仍需进一步探索。Tissue heterotopic ossification is an erroneous repair process of soft tissue,which is a common complication of surgery and traumatic injury.It has a high incidence,especially in the military,a large number of the wounded have various forms of heterotopic ossification,which is a major problem to be solved in clinical practice.However,the pathogenesis of heterotopic ossification has not yet been fully elucidated,resulting in the difficulty in the treatment.Peripheral nerves play a pivotal pathogenic role in the occurrence and development of heterotopic ossification,mainly through the following three aspects:neuroinflammation-induced opening of blood-nerve barrier,neural stem cells migrating to bone deposition sites and differentiating into osteoblasts,and peripheral nerve regulating brown adipose tissue to promote cartilage osteogenesis and angiogenesis.In the future,how to apply the regulation of peripheral nerve activity to the treatment of tissue heterotopic ossification still needs further exploration.

关 键 词：异位矿化 外周神经 神经炎症 神经干细胞 成骨细胞 

分 类 号：R681[医药卫生—骨科学]