血清CysC与尿NAG、RBP联合检测在2型糖尿病早期肾损伤中的应用  

Application of Combined Detection of Serum CysC,Urine NAG and RBP in Early Renal Injury of Type 2 Diabetes

作　　者：任风梅 REN Feng-mei(Wucheng County Traditional Chinese Medicine Hospital,Wucheng,Shandong Province,253300 China)

机构地区：[1]武城县中医院,山东武城253300

出　　处：《糖尿病新世界》2020年第13期194-195,198,共3页Diabetes New World Magazine

摘　　要：目的探讨血清血清胱抑素(CysC)与尿β-N-乙酰葡萄糖苷酶(NAG)、尿视黄醇结合蛋白(RBP)联合检测在2型糖尿病早期肾损伤中的应用。方法选择2018年5月—2019年5月该院收治的47例2型糖尿病早期肾损伤患者作为研究组,选择同期该院收治的47例2型糖尿病患者作为对照组。对比两组患者血清CysC与尿液NAG、RBP水平。同时,对比单项血清CysC指标、尿液NAG、RBP指标与3项指标联合诊断2型糖尿病早期肾损伤的阳性率。结果研究组血清CysC指标与尿液NAG、RBP指标均高于对照组(P<0.05)。3项指标联合诊断的阳性率95.74%高于单项血清CysC指标阳性率76.60%、尿液NAG阳性率74.47%与RBP阳性率76.60%(P<0.05)。结论血清CysC与尿NAG、RBP联合检测2型糖尿病早期肾损伤效果可靠。Objective To explore the application of combined detection of serum cystatin(CysC),urineβ-N-acetylglucosidase(NAG)and urinary retinol binding protein(RBP)in early renal injury of type 2 diabetes.Methods From May 2018 to May 2019,47 patients with type 2 diabetes and early kidney injury treated in the hospital were selected as the research group,and 47 patients with type 2 diabetes admitted in the hospital during the same period were selected as the control group.The serum CysC and urine NAG and RBP levels were compared between the two groups.At the same time,the positive rate of early diagnosis of kidney injury in type 2 diabetes was compared between the single serum CysC index,urine NAG,RBP index and three indexes.Results The serum CysC index and urine NAG and RBP indexes in the study group were higher than those in the control group(P<0.05).The positive rate of the combined diagnosis of the three indicators was 95.74%higher than the single serum CysC indicator positive rate of 76.60%,urine NAG positive rate of 74.47%and RBP positive rate of 76.60%(P<0.05).Conclusion The combination of serum CysC,urine NAG and RBP in the detection of early renal injury in type 2 diabetes is reliable.

关 键 词：血清CYSC 尿NAG RBP 2型糖尿病 早期肾损伤 

分 类 号：R59[医药卫生—内科学]