新型异噁唑山酮素骨架螺环氧化吲哚类化合物的合成  

Synthesis of Novel Isoxazole-fused Xanthone-based Spirooxindoles

作　　者：景德红 韦启迪 刘雄利[2] JING De-hong;WEI Qi-di;LIU Xiong-li(Southwest Guizhou Vocational & Technical College for Nationalities, Xingyi 562400, China;Guizhou Medicine Edicine Edible Plant Resources Research and Developmant Center, Guizhou University, Guiyang 550025, China)

机构地区：[1]黔西南民族职业技术学院,贵州兴义562400 [2]贵州大学贵州省药食同源植物资源开发工程技术研究中心,贵州贵阳550025

出　　处：《合成化学》2020年第9期820-824,共5页Chinese Journal of Synthetic Chemistry

基　　金：国家自然科学基金资助项目(81760625)。

摘　　要：以色酮-氧化吲哚合成子(1)与硝基异噁唑苯乙烯(2),催化剂DBU作用下,经分子间Michael加成,分子内Michael加成环化反应,获得7个新型异噁唑山酮素骨架螺环氧化吲哚类化合物3a^3g,产率87%~93%,dr=8/1~15/1,其结构经1H NMR,13C NMR和HR-MS(ESI-TOF)表征。Seven novel isoxazole-fused xanthone-based spirooxindoles(3a^3g)were synthesized via an DBU-catalyzed inter-/intramolecular Michael cycloaddition of oxindole-chromone synthons(1)with 3-methyl-4-nitro-5-alkenyl-isoxazoles(2).The yields and dr of 3a^3g were 87%~93%and 8/1~15/1,respectively.The structures were characterized by 1H NMR,13C NMR and HR-MS(ESI-TOF).

关 键 词：色酮-氧化吲哚合成子 硝基异噁唑苯乙烯 Michael加成环化反应 异噁唑山酮素骨架螺环氧化吲哚类化合物 合成 

分 类 号：O626.13[理学—有机化学] O623.7[理学—化学]