硫代核苷类似物的合成研究进展  

Research Progress in Synthesis of Thionucleoside Analogs

作　　者：李洋 崔琳琳[1,2] 邢志华[1,2] 刘颖杰[1,2] 袁甜 申光焕[1,2] LI Yang;CUI Lin-lin;XING Zhi-hua;LIU Ying-jie;YUAN Tian;SHEN Guang-huan(College of Pharmacy,Harbin University of Commerce,Harbin 150076,China;Heilongjiang Provincial Key Laboratory of Drug Prevention and Treatment for Senile Diseases,Harbin University of Commerce,Harbin 150076,China)

机构地区：[1]哈尔滨商业大学药学院,黑龙江哈尔滨150076 [2]哈尔滨商业大学黑龙江省预防与治疗老年性疾病药物研究重点实验室,黑龙江哈尔滨150076

出　　处：《合成化学》2020年第9期830-839,共10页Chinese Journal of Synthetic Chemistry

基　　金：黑龙江省留学回国人员择优资助项目(18930101);哈尔滨商业大学博士科研启动项目(2019DS116)。

摘　　要：4′-硫代核苷类似物是核糖环中的氧原子被硫原子取代的核苷类似物。许多硫代核苷具有良好的抗病毒和抗肿瘤活性。4′-硫代核苷具有更稳定的糖基键和针对各种病毒或细胞酶的代谢稳定性的提升等固有优点。因此,对硫代核苷类似物的设计与合成,筛选出安全有效的抗病毒试剂应受到更多药物化学家们的关注,本文综述了近年来硫代核苷的合成研究进展。The 4′-thionucleoside analogs are nucleoside analogs in which the oxygen atom in the ribose ring is replaced by a sulfur atom.Many thionucleosides show potent antiviral or antitumor activities.4′-thinucleosides have inherent advantages such as having a more stable glycosyl bond and increased metabolic stability against various viral or cellular enzymes.Therefore,medicinal chemists have focused their attention on designing and preparing new thionucleoside analogues,in efforts to discover new more powerful and safe antiviral agents.The syntheses of thionucleosides in recent years are reviewed in this article.

关 键 词：4′-硫代核苷 合成 抗肿瘤 抗病毒 抑制剂 综述 

分 类 号：R28[医药卫生—中药学]