硬/软质人工授精导管的使用对供精人工授精妊娠结局影响的比较  

Comparison of the effect of rigid/flexible artificial insemination catheter on pregnancy outcome of artificial insemination by donor

作　　者：王佳佳 吴欢[1,2,3,4,5] 李欣媛[1,2,3,4,5] 贺小进[1,2,3,4,5] 曹云霞 Wang Jiajia;Wu Huan;Li Xinyuan(Dept of Obstetrics and Gynecology,The First Affiliated Hospital of Anhui MePical UniversitA,Hefei 230022;NHC Key Laborators of Study oo Abnormal Gametes and ReprofuctAe Tract(Anhui MePical Unierspy),Hefei 230032;Key Laborators of Pogulatioo Health Across Life Cycle(Anhui MePical University),Ministrs of Education of ihe People s Republic of China,Hefei 230032;Anhui Provincc Kep Laborators of ReproductAe Health and Genetics(Anhui Medical Unfersif),Hefei 230032;BiopreservaAor and Artifial Organs,Anhui Provincial Engineering Research Center(Anhui MePical University),Hefei 230032)

机构地区：[1]安徽医科大学第一附属医院妇产科,合肥230022 [2]国家卫生健康委配子及生殖道异常研究重点实验室(安徽医科大学),合肥230032 [3]出生人口健康教育部重点实验室(安徽医科大学),合肥230032 [4]生殖健康与遗传安徽省重点实验室(安徽医科大学),合肥230032 [5]安徽省生命资源保存与人工器官工程技术研究中心(安徽医科大学),合肥230032

出　　处：《安徽医科大学学报》2020年第8期1227-1231,共5页Acta Universitatis Medicinalis Anhui

基　　金：安徽省自然科学基金(编号:1908085QH313)。

摘　　要：目的比较硬/软质人工授精导管的使用对供精人工授精妊娠结局的影响。方法回顾性分析了2747个供精人工授精(AID)周期的临床资料,根据术中使用的硬/软质人工授精导管分为硬导管组和软导管组。组内根据卵泡发育方案分为硬质导管-自然周期组,硬质导管-促排卵周期组,软质导管-自然周期组,软质导管-促排卵周期组;根据每AID周期中宫腔内人工授精(IUI)次数分为硬质导管-单次授精组,硬质导管-双次授精组,软质导管-单次授精组,软质导管-双次授精组,分析比较了各组之间的生化妊娠率、临床妊娠率、活产率、多胎妊娠率、流产率。结果软质导管-单次授精组的生化妊娠率、临床妊娠率、活产率均高于硬质导管-单次授精组,差异有统计学意义(P<0.05),两组的流产率差异无统计学意义,除此之外,其他的硬质导管组与软质导管组AID治疗的生化妊娠率、临床妊娠率、活产率、多胎妊娠率、流产率差异均无统计学意义(均P>0.05)。结论AID治疗过程中使用软质导管与使用硬质导管的妊娠结局没有差异,但当AID周期中IUI次数为单次时,使用软质导管的妊娠结局比硬质导管好。Objective To compare the effect of rigid/flexible artificial insemination catheter on pregnancy outcome of artificial insemination by donor.Methods The clinical data of 2747 artificial insemination by donor(AID)cycles were analyzed retrospectively.According to the rigid/flexible artificial insemination catheter used in the operation,they were divided into rigid catheter group and flexible catheter group.According to the follicular development scheme,they were furtherly divided into rigid catheter-natural cycle group,rigid catheter-promoted ovulation cycle group,flexible catheter-natural cycle group and flexible catheter-promoted ovulation cycle group.And according to the times of intrauterine insemination(IUI)in each AID cycle,they were furtherly divided into rigid catheter-single insemination group,rigid catheter-double insemination group,flexible catheter-single insemination group and flexible catheter-double insemination group.Then the biochemical pregnancy rate,clinical pregnancy rate,live birth rate,multiple pregnancy rate and abortion rate among the groups were compared and analyzed.Results The biochemical pregnancy rate,clinical pregnancy rate and live birth rate of the flexible catheter-single insemination group were higher than those of the rigid catheter-single insemination group,and the difference had statistical significance(P<0.05).The difference between the abortion rates of the two groups had no statistical significance.In addition,the biochemical pregnancy rate,clinical pregnancy rate,live birth rate,multiple pregnancy rate and abortion rate of other rigid catheter groups and flexible catheter groups had no statistical significance(all P>0.05).Conclusion There is no difference in pregnancy outcome between using flexible catheters and rigid catheters in AID treatment.However,when there is only single IUI in an AID cycle,the pregnancy outcome of using flexible catheters is better than that of using rigid catheters.

关 键 词：供精人工授精 硬质导管 软质导管 妊娠结局 

分 类 号：R711.6[医药卫生—妇产科学]