PCOS患者冷冻胚胎移植后双胎妊娠结局分析  

Analysis of twin pregnancy outcome after frozen-embryo transfer in PCOS patients

作　　者：王芳芳 李君 李彩华 徐玉萍[1,3,4] 邢琼 章志国[1,3,4] 曹云霞 魏兆莲[1,3,4] Wang Fangfang;Li Jun;Li Caihua(Dept of Obtetrics and Gynecology,The First Afiliated Hospital of Anhui Medical University,Hefei 230022;Dept of Obtrics and Gynecology,The Attached Anqing Hospital of Anhui Medical University,Anqing 246003;Anhui Province Key Laboratory of Reproductive Health and Genetics,Hefei 230022;Biopreservation and Arificial Organs,Anhui Prorincial Engineering Researeh Center,Anhui Medical University,Hefei 230022)

机构地区：[1]安徽医科大学第一附属医院妇产科,合肥230022 [2]安徽医科大学附属安庆医院妇产科,安庆246003 [3]安徽医科大学生殖健康与遗传安徽省重点实验室,合肥230022 [4]安徽省生命资源保存与人工器官工程技术研究中心,合肥230022

出　　处：《安徽医科大学学报》2020年第8期1237-1240,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省重点研究和开发计划项目(编号:1804h08020265)。

摘　　要：目的分析多囊卵巢综合征(PCOS)不孕患者冷冻胚胎移植后所获双胎的妊娠结局。方法回顾性分析接受体外受精-冷冻胚胎移植且获得双胎妊娠的患者1449例,PCOS组为多囊卵巢综合征因素导致不孕的患者421例,对照组为同期因单纯输卵管因素导致不孕的患者1028例,两组患者根据体质量指数(BMI)又分为非超重组(BMI<24 kg/m^2)和超重组(BMI≥24 kg/m^2),记为:非超重PCOS组、超重PCOS组;非超重对照组、超重对照组。分别比较非超重PCOS组与非超重对照组、超重PCOS组与超重对照组的一般资料、妊娠期并发症以及新生儿结局。结果非超重PCOS组流产率及晚期流产率大于非超重对照组,差异有统计学意义(P<0.05),两组早期流产率、早产率、妊娠期高血压疾病发生率、妊娠期糖尿病发生率、剖宫产率、新生儿平均出生体质量、新生儿畸形率差异无统计学意义。超重PCOS组新生儿平均出生体质量小于超重对照组,流产率及晚期流产率大于超重对照组,差异有统计学意义(P<0.05),两组早期流产率、早产率、妊娠期高血压疾病发生率、妊娠期糖尿病发生率、剖宫产率及新生儿畸形率差异无统计学意义。结论PCOS患者冷冻胚胎移植后所获双胎妊娠的流产率及晚期流产率增加,且超重PCOS患者新生儿出生体质量降低。Objective To analyze the pregnancy outcome of twins in infertile women with polycystic ovary syndrome(PCOS)after the frozen-embryo transfer.Methods Retrospective analysis was made on 1449 patients who received in vitro fertilization-frozen embryo transfer and obtained twin pregnancy.The PCOS group was 421 patients with infertility caused by polycystic ovary syndrome,and the control group was 1028 patients with infertility caused by fallopian tube factors alone in the same period.The two groups of patients were further respectively divided into non-overweight group(BMI<24 kg/m^2)and overweight group(BMI≥24 kg/m^2),which were recorded as:non-overweight PCOS group,overweight PCOS group;non-overweight control group,overweight control group.General information,pregnancy complications,and neonatal outcomes of non-overweight PCOS group and non-overweight control group were compared,which were also compared between the overweight PCOS group and the overweight control group.Results The abortion rate and late abortion rate in non-overweight PCOS group were higher than those in the non-overweight control group(P<0.05).There was no significant difference in early abortion rate,premature delivery rate,morbidity of hypertensive disorders of pregnancy(HDP)、gestational diabetes mellitus(GDM),cesarean section rate,average weight and malformation rate of newborn between the two groups.The mean neonatal birth weight in overweight PCOS group was lower than that in overweight control group;abortion rate and late abortion rate in PCOS group were higher than those in overweight control group(P<0.05).There was no significant difference in early abortion rate,premature delivery rate,morbidity of HDP、GDM,cesarean section rate and neonatal malformation rate between the two groups.Conclusion PCOS after frozen-embryo transfer increase the pregnancy abortion rate and late abortion rate of twins,and PCOS in overweight patients reduce the neonatal birth weight.

关 键 词：多囊卵巢综合征 体外受精-胚胎移植 双胎妊娠 结局 

分 类 号：R711.6[医药卫生—妇产科学]