武汉地区正常单胎妊娠胎儿早期NT厚度正常值分析  

Analysis of the normal value of fetal NT value of pregnant women with normal single-fetus pregnancy during the first trimester of pregnancy in Wuhan area

作　　者：马玉成 韦卫中[1] 何晓俊 MA Yucheng;WEI Weizhong;HE Xiaojun(Wuhan Children's Hospital Affiliated to Tongji Medical College, Huazhong University of Science and Technology(Wuhan Maternal and Child Health Care Hospital), Hubei Province, 430000)

机构地区：[1]华中科技大学同济医学院附属武汉儿童医院(武汉市妇幼保健院),430000

出　　处：《中国计划生育学杂志》2020年第8期1321-1324,共4页Chinese Journal of Family Planning

摘　　要：目的:探讨武汉地区孕妇早孕期胎儿颈项透明层(NT)正常值范围以及与孕龄、孕妇年龄、胎儿性别等相关性。方法:连续性选择2013年1月—2017年12月在本院行产前超声检查的孕11~13周+6单胎汉族孕妇3671例,超声测量胎儿NT厚度,分析正常胎儿NT厚度建立正常参考值范围,观察不同孕龄、孕妇年龄、胎儿性别NT厚度的差异和正常参考值范围。Pearson分析NT值与孕龄、孕妇年龄的相关性。结果:本组3548例完成胎儿NT厚度测量,成功测量率96.7%,其中3316例完成随访,随访成功率93.5%,剔除43例流产、死胎、出生缺陷胎儿,3273例单胎孕妇最终进入结果分析。3273例正常胎儿NT厚度值符合正态分布,NT厚度为1.73±0.68mm,95%参考范围为0.78~2.85mm。男性胎儿NT厚度值大于女性胎儿,年龄>35岁孕妇的胎儿NT厚度值大于≤35岁孕妇胎儿(均P<0.05)。Pearson相关性分析,胎儿NT厚度与孕妇年龄呈正相关(r=0.419,P<0.05),与孕龄无关(r=0.130,P>0.05)。结论:本院孕妇早孕期胎儿NT值95%参考范围为0.78~2.85mm,高龄孕妇胎儿NT厚度增加。Objective:To explore the normal range of fetal NT value of pregnant women with normal single-fetus pregnancy during the first trimester of pregnancy in Wuhan area,and to study the fetal NT value correlation with gestational weeks,maternal age,and fetal gender.Methods:3617 pregnant women with normal single-fetus pregnancy during 11-13 gestational weeks from January 2013 to December 2017 were selected in this study continually.Fetal NT values of these women were measured by ultrasound.The normal reference range of NT value of normal single fetus was established.The differences of NT value of fetus and its normal reference range of women with different gestational weeks,maternal age,or fetal sex were observed.Pearson analysis was used to explore the correlation between NT value and gestational weeks and maternal age.Results:There were 3548 women completed fetal NT value measurement,which’s successful measurement rate was 96.7%.Among them,3316 women were followed up,which’s success followed up rate was 93.5%,and the date of 3273 women with single-fetal pregnancy were finally included for analysis except to 43 women with abortion,dead fetal,or birth defects.The NT value of 3273 normal fetuses was in accordance with the normal distribution.The normal fetus NT value was 1.73±0.68 mm,which’s 95%reference range was 0.78-2.85 mm.The NT value of normal male fetus was significant more than that of female fetus.The fetal NT value of women over 35 years old was more than women egual to or less than 35 years old(all P<0.05).Pearson correlation analysis showed that NT value was positively correlated with maternal age(r=0.419,P<0.05),but had no correlation with gestational weeks(r=0.130,P>0.05).Conclusion:The 95%reference range of fetal NT value of pregnant women with normal single-fetus pregnancy during the first trimester of pregnancy in Wuhan area is 0.78-2.85mm,and the NT value of elderly pregnant women increases.

关 键 词：妊娠早期 产前超声检查 胎儿颈项透明层 正常值范围 相关性 

分 类 号：R714.5[医药卫生—妇产科学]