补益肺肾法治疗变应性哮喘的疗效及对T辅助细胞亚群平衡的影响  

Effect of Tonifying Lung and Kidney Therapy on Allergic Asthma and its Effect on Balance of T Helper Cell Subsets

作　　者：陈宏[1] 张伟[1] 苏玉明[1] 陈群[2] 宋倩男 王昕宇 李美蓄 张菁 迟媛 隋博文[1] CHEN Hong;ZHANG Wei;SU Yuming;CHEN Qun;SONG Qiannan;WANG Xinyu;LI Meixu;ZHANG Jing;CHI Yuan;SUI Bowen(First Affiliated Hospital,Heilongjiang University of Chinese Medicine,Harbin 150040,China;the People’s Hospital of Acheng District of Harbin City,Harbin 150300,China;Heilongjiang University of Chinese Medicine,Harbin 150040,China)

机构地区：[1]黑龙江中医药大学附属第一医院,哈尔滨150040 [2]哈尔滨市阿城区人民医院,哈尔滨150300 [3]黑龙江中医药大学,哈尔滨150040

出　　处：《吉林中医药》2020年第8期1044-1046,共3页Jilin Journal of Chinese Medicine

基　　金：黑龙江省自然科学基金面上项目(H2018052)。

摘　　要：目的探讨补益肺肾法治疗变应性哮喘的疗效及对T辅助细胞亚群平衡的影响。方法选择2016年6月-2018年7月收治的变应性哮喘患儿120例,采用随机数字表法,将患儿分为观察组与对照组,各60例。对照组予以常规西药治疗,观察组在此基础上予以补益肺肾法治疗,比较2组疗效。结果观察组治疗后的FEV1(0.93±0.09)L、PEF(1.62±0.13)L/S、PVC(1.15±0.09)L、PD20FEV1(5.68±1.39)μmol/L水平高于对照组,2组比较差异具有统计学意义(P<0.05)。观察组治疗后的Th1(21.42±1.56)%、Th1/Th1(6.39±1.17)水平高于对照组(P<0.05)、Th2(3.36±0.15)%水平低于对照组,2组比较差异具有统计学意义(P<0.05)。治疗后2组活动受限、哮喘症状、心理状况、对刺激源反应、对自身健康的关心评分差异显著,具有统计学意义(P<0.05)。结论补益肺肾法治疗可有效调节变应性哮喘患儿T辅助细胞亚群平衡,降低气道反应性,改善肺功能,疗效良好,值得推广。Objective To investigate the effect of tonifying lung and kidney therapy on allergic asthma and the balance of T helper cell subsets.Methods 120 patients with allergic asthma admitted to our hospital from June 2016 to July 2018 were randomly divided into observation group and control group,60 cases in each group.The control group was treated with routine western medicine,while the observation group was treated with the method of tonifying lung and kidney on the basis of this,and the curative effects of the two groups were compared.Results After treatment,the levels of FEV1 (0.93±0.09) L,PEF (1.62±0.13) L/S,PVC (1.15±0.09) L and PD20FEV1 (5.68±1.39) μmol/L in the observation group were higher than those in the control group (P<0.05).After treatment,the levels of Th1 (21.42±1.56)%,Th1/Th1 (6.39±1.17) in the observation group were higher than those in the control group (P<0.05),and Th2 (3.36±0.15)% were lower than those in the control group (P<0.05).After treatment,there were significant differences between the two groups in activity limitation,asthma symptoms,psychological status,stimulus response,and self-care score (P<0.05).Conclusion The therapy of tonifying lung and kidney can effectively regulate the balance of T helper cell subsets,reduce airway reactivity and improve lung function in patients with allergic asthma.

关 键 词：变应性哮喘 补益肺肾法 T辅助细胞亚群 

分 类 号：R256.1[医药卫生—中医内科学]