血常规检查在未足月胎膜早破诊断中的价值  

Diagnostic Value of Blood Routine Test in Diagnosis of Preterm Premature Rupture of Membranes

作　　者：陈竹雨 孙孟雄 张鸿清 宁建峰 CHEN Zhu-yu;SUN Meng-xiong;ZHANG Hong-qing;NING Jian-feng(Department of Clinical Laboratory,The First Hospital of Zhangjiakou City,Zhangjiakou,Hebei 075000,China)

机构地区：[1]张家口市第一医院检验科,河北张家口075000

出　　处：《河北北方学院学报（自然科学版）》2020年第10期12-15,18,共5页Journal of Hebei North University:Natural Science Edition

摘　　要：目的探讨血常规检查对未足月胎膜早破(preterm premature rupture of membrane,pPROM)的预测价值。方法回顾性分析60例未足月胎膜早破孕产妇(观察组)和60例足月妊娠孕产妇(对照组)的血常规检查结果,比较2组血常规参数,并对差异有显著性的参数建立接受者操作特性曲线(ROC曲线),计算曲线下面积、敏感性、特异性、阳性预测值和阴性预测值。结果观察组孕产妇年龄显著高于对照组,孕产妇年龄越大,pPROM发生的可能性越高;组间WBC、LYMPH%、NEUT%、NEUT#、RBC、HGB、HCT及NLR差异有显著性(P<0.05)。ROC曲线显示以WBC>9.65与NEUT#>7.13为cut off值联合检测为最佳组合,AUC为0.767,敏感性为71%,特异性为83%,阳性预测值为80.2%,阴性预测值为76%。结论血常规检查结果可用于预测胎膜早破,为提高诊断敏感性和特异性,可对多个参数进行联合检测。Objective To investigate the predictive value of blood routine test for preterm premature rupture of membrane(pPROM).Methods A retrospective study was conducted on blood routine test data from 60 cases of pPROM(pPROM group)and 60 cases of full-term pregnancy(control group).All blood routine parameters were compared between two groups,the receiver operating characteristic curve(ROC)was established for the parameters with significant difference,and the area under curve(AUC),sensitivity,specificity,positive predictive value and negative predictive value were further calculated.Results The age of pregnant women in the pPROM group was significantly higher than that in the control group,and the older the pregnant woman was,the higher the probability of pPROM was.There were significant differences in several blood routine parameters between the two groups,including WBC,LYMPH%,NEUT%,NEUT#,RBC,HGB,HCT and NLR(P<0.05).The ROC established showed that when the cut off value was WBC>9.65 and NEUT#>7.13,the combined detection had the best predictive value with AUC of 0.767,sensitivity of 71%,and specificity of 83%.Its positive and negative predictive values were 80.2%and 76%,respectively.Conclusion The results of blood routine test can be used to predict pPROM,and multiple parameters can be combined to improve the sensitivity and specificity.

关 键 词：血常规 胎膜早破 未足月胎膜早破 诊断价值 

分 类 号：R714.433[医药卫生—妇产科学]