白色脂肪棕色化在脂肪代谢调控中的研究进展  

Research progress of white fat browning in regulation of fat metabolism

作　　者：刘磊[1] 王勇[2] 赵羲和[3] 何冰[4] Lei Liu;Wang Yong;Zhao Xihe;He Bing(Department of General Surgery,Shengjing Hospital of China Medical University,Liaoning 110022,China;Department of General Surgery,the Forth Hospital of China Medical University Liaoning 110032,China;Department of Clinical Oncology,Shengjing Hospital of China Medical University,Liaoning 110022,China;Department of Endocrinology,Shengjing Hospital of China Medical University,Liaoning 110004,China)

机构地区：[1]中国医科大学附属盛京医院普通外科,辽宁110022 [2]中国医科大学附属第四医院普通外科,辽宁110032 [3]中国医科大学附属盛京医院肿瘤科,辽宁110022 [4]中国医科大学附属盛京医院内分泌科,辽宁110004

出　　处：《国际外科学杂志》2020年第8期572-576,共5页International Journal of Surgery

基　　金：国家自然科学基金青年基金项目(81702402、81802760);国家自然科学基金面上项目(81570765);辽宁省博士启动基金项目(20170520027)。

摘　　要：哺乳动物体内的脂肪组织根据其颜色和功能可划分为白色脂肪组织和棕色脂肪组织。白脂肪组织在交感神经兴奋等条件下能诱导产生一种新型脂肪细胞——米色脂肪细胞。白色脂肪受到诱导和激活从而产生米色脂肪组织的过程被称为白色脂肪棕色化。白色脂肪和米色脂肪之间的比例动态平衡与机体代谢稳态关系密切。研究脂肪组织的白色向棕色化转化过程的信号传导途径,可以为纠正肥胖,缓解肥胖相关糖脂代谢紊乱提供新的思路。本文就白色脂肪棕色化在代谢调控中的作用、意义及其影响因素等进行阐述。The adipose tissue in mammalian can be classifieded into white adipose tissue and brown adipose tissue according to color and function.White adipose tissue can change into a new type of adipocyte--Beige adipocyte under the condition such as sympathetic excitation.The process white adipose tissue is induced to produce beige adipose tissue is called browning of white adipose tissue.The dynamic balance between white adipose tissue and beige adipose tissue is closely related to the homeostasis of metabolism.Studying the signal transduction pathway of the white to brown transformation of adipose tissue can provide a new way to correct obesity and alleviate the disorder of obesity related glucose and lipid metabolism.The role,significance and influencing factors in metabolic regulation of white adipose tissue browning were discussed in this paper.

关 键 词：白色脂肪 棕色脂肪 肥胖症 

分 类 号：R589.2[医药卫生—内分泌]