药物经济学评价中的分区生存模型  

Partitioned survival model in pharmacoeconomics

作　　者：曾小慧[1] 彭六保[2] 谭重庆[2] 万小敏[2] 王云华[1] ZENG Xiao-hui;PENG Liu-bao;TAN Chong-qing;WAN Xiao-min;WANG Yun-hua(PET Imaging Center,the Second Xiangya Hospital of Central South University,Changsha HU-MN 410011,ChinaDepartment of Pharmacy,the Second Xiangya Hospital of Central South University,Changsha HU-MN 410011,China)

机构地区：[1]中南大学湘雅二医院PET影像中心,湖南长沙410011 [2]中南大学湘雅二医院药学部,湖南长沙410011

出　　处：《中国新药与临床杂志》2020年第8期504-507,共4页Chinese Journal of New Drugs and Clinical Remedies

基　　金：国家自然科学基金(81401547,81603081)。

摘　　要：分区生存模型(PSM)是近年来药物经济学评价中使用比较多的一种决策模型,用于解决决策相关的异质性和不确定性问题。PSM通过对总体生存曲线进行分区或分离得到不同的健康状态,直接利用一组生存曲线确定各个状态的个体数量或比例(即状态成员),避免了转移概率的计算,并且避免了不必要的模型假设对研究结果的影响,为使用临床试验数据构建药物经济学评价模型提供了一种方便可行的方法。Partitioned survival model(PSM),which is used to solve the heterogeneity and uncertainty related to decision-making,and as a decision modeling approach,is widely used in pharmacoeconomic evaluations in recent years.In the PSM,overall survival curve is disaggregated or partitioned into different health states,and the number or proportion of individuals in each state(state membership)is not estimated using transition probabilities,but determined from a set of survival curves.PSM also avoids the influence of unnecessary model assumptions on the research results and provides a convenient and feasible method for the construction of pharmacoeconomic evaluation models using data of clinical trials.

关 键 词：经济学 药学 分区生存模型 决策模型 成本及成本分析 

分 类 号：R956[医药卫生—药学]