Biomimetic Asymmetric Reduction of Quinazolinones with Chiral and Regenerable NAD(P)H Models  

作　　者：Zi-Biao Zhao Xiang Li Bo Wu Yong-Gui Zhou 

机构地区：[1]State Key Laboratory of Catalysis,Dalian Institute of Chemical Physics,Chinese Academy of Sciences,Dalian,Liaoning 116023,China [2]State Key Laboratory of Organometallic Chemistry,Shanghai Institute of Organic Chemistry,Chinese Academy of Sciences,Shanghai 200032,China

出　　处：《Chinese Journal of Chemistry》2020年第7期714-718,共5页中国化学（英文版）

基　　金：the National Natural Science Foundation of China(21532006,21690074);Chinese Academy of Sciences(XDB17020300,QYZDJ-SSW-SLH035)is acknowledged.

摘　　要：A facile approach to chiral dihydroquinazolinone derivatives has been described wia biomimetic asym-metric reduction of quinazolinones with chiral and regenerable NAD(P)H models.The utiity of this method was demonstrated by a concise synthesis of the bromodomain protein divalent inhibitor.

关 键 词：CHIRAL CHIRAL CONCLUSION 

分 类 号：O62[理学—有机化学]