东莞市茶山镇成年人血脂异常与高尿酸血症的关系  

Association between hyperuricemia and dyslipidemia in Chinese adults from Chashan,Dongguan

作　　者：饶媛 刘宏艺 梁结玲 管裕 古洁若[2] 杨明灿[2] Rao Yuan;Liu Hongyi;Liang Jieling;Guan Yu;Gu Jieruo;Yang Mingcan(Dongguan Chashan Hospital,Dongguan 523380,China)

机构地区：[1]东莞市茶山医院,东莞523380 [2]中山大学附属第三医院风湿免疫科,广州510630

出　　处：《新医学》2020年第9期718-723,共6页Journal of New Medicine

摘　　要：目的调查东莞市茶山镇成年人高尿酸血症(HUA)患病率情况,及其与血脂、性别和年龄的相关性。方法采用回顾性研究方法,调取东莞市茶山医院2018年2697名成年体检者的资料,收集性别、年龄及血清尿酸、甘油三酯、总胆固醇、LDL-C和HDL-C检测结果并进行统计分析。结果共纳入男1545名、女1152名,HUA总体患病率38.90%(1049/2697),其中男性HUA患病率高于女性(49.77%vs.24.31%,P<0.001)。无论男、女性体检者,HUA组的血清尿酸、总胆固醇、甘油三酯、LDL-C水平均高于非HUA组;HUA组的HDL-C水平低于非HUA组;HUA组血脂升高者比例高于非HUA组(P<0.001)。相关性分析显示,男性和女性体检者中,血清尿酸水平与总胆固醇、甘油三酯、LDL-C均呈正相关,而与HDL-C均呈负相关(P均<0.01)。多因素Logistic回归分析显示,男性HUA患病风险是女性的2.544倍(OR=2.544,95%CI 2.131~3.036,P<0.001),年龄≥65岁组是18~24岁组HUA患病风险的2.341倍(OR=2.341,95%CI 1.336~4.105,P=0.003),随着甘油三酯和胆固醇水平的增加,HUA患病风险均有不同程度的增加(P均<0.05)。结论东莞市茶山镇体检人群中成年人HUA患病率整体处于较高水平。血清尿酸水平与总胆固醇、甘油三酯、LDL-C呈正相关,而与HDL-C呈负相关。男性、高龄(年龄≥65岁)和高血脂是HUA的危险因素。Objective To investigate the prevalence of hyperuricemia(HUA)among adults from Chashan,Dongguan,and analyze its correlation with blood lipids,gender and age.Methods In this retrospective study,clinical data of 2697 adults undergoing physical examination in Chashan Hospital of Dongguan in 2018 were collected and statistically analyzed,which included sex,age,uric acid(UA),triglyceride(TG),total cholesterol(TC),low-density lipoprotein cholesterol(LDL-C)and high-density lipoprotein cholesterol(HDL-C).Results A total of 1545 male and 1152 female individuals were included.The overall prevalence of HUA was 38.90%(1049/2697).The prevalence of HUA in men was significantly higher than that in females(49.77%vs.24.31%,P<0.001).The average UA,TC,TG,and LDL-C levels in the HUA group were significantly higher than those in the non-HUA group,regardless of gender.The average HDL-C level in the HUA group were significantly lower than that in the non-HUA group(P<0.001).Correlation analysis showed that for both male and female individuals,the UA levels were positively correlated with the TC,TG and LDL-C levels,whereas negatively correlated with the HDL-C level(all P<0.01).Multivariate Logistic analysis revealed that the risk of HUA in men was 2.544 times that of women(OR=2.544,95%CI 2.131-3.036,P<0.001).The risk of HUA in patients aged≥65 years old was 2.341 times that of their counterparts aged 18-24 years(OR=2.341,95%CI 1.336-4.105,P=0.003).The risk of HUA was increased to varying degrees along with the increase of TG and TC levels(both P<0.05).Conclusions The prevalence of HUA is relatively high among the adults receiving physical examination from Chashan,Dongguan.The UA level is positively correlated with the TC,TG and LDL-C levels,whereas negatively correlated with the HDL-C level.Male,old age(age≥65 years)and hyperlipidemia are the risk factors of HUA.

关 键 词：甘油三酯 总胆固醇 高尿酸血症 患病率 危险因素 

分 类 号：R589.7[医药卫生—内分泌]