肾移植术后采用他克莫司和环孢素抗排斥药物治疗的临床效果研究  

Clinical effect of tacrolimus and cyclosporine in the treatment of rejection after renal transplantation

作　　者：陈蕴 郑晓琼[1] CHEN Yun;ZHENG Xiao-qiong(Pharmacy department of the first affiliated hospital of SUN YAT-SEN University,Guangzhou 510080,China)

机构地区：[1]中山大学附属第一医院药学部,广州510080

出　　处：《中国处方药》2020年第9期110-111,共2页Journal of China Prescription Drug

摘　　要：目的探讨肾移植术后采用他克莫司和环孢素抗排斥药物治疗的临床效果。方法选取肾移植术患者66例,按照随机数字表法,分为对照组与观察组,各33例。对照组应用环孢素、吗替麦考酚酯联合泼尼松治疗,观察组应用他克莫司、吗替麦考酚酯联合泼尼松治疗,比较两组药物排斥发生率与肝肾功能指标。结果两组药物排斥发生率、尿素氮(BUN)与血肌酐(Scr)水平差异无统计学意义(P>0.05);观察组丙氨酸氨基转移酶(ALT)、碱性磷酸酶(ALP)、谷草转氨酶(AST)与γ-谷酰转肽酶(γ-GT)水平均低于对照组,差异具有统计学意义(P<0.05)。结论肾移植术后采用他克莫司作为抗排斥药物,可使患者机体肝功能得到更为有效保护,效果优于环孢素。Objective To investigate the clinical effect of tacrolimus and cyclosporine in the treatment of rejection after renal transplantation.Methods 66 patients with renal transplantation were divided into control group and observation group,33 cases in each group.The control group was treated with cyclosporine,mycophenolate and prednisone.The observation group was treated with tacrolimus,pramipexorubicin combined with prednisone.The rate of drug rejection and the index of liver and kidney function were compared between the two groups.Results There was no significant difference in drug rejection rate,bun and SCR between the two groups(P>0.05).The levels of ALT,ALP,AST andγ-GT in the observation group were lower than those in the control group,and the difference was statistically significant(P<0.05).Conclusion Tacrolimus can be used as an anti rejection drug after kidney transplantation,which can protect the liver function of patients more effectively,and the effect is better than cyclosporine.

关 键 词：肾移植术 他克莫司 环孢素 抗排斥药物 

分 类 号：R699.2[医药卫生—泌尿科学]