“孔雀开屏”组穴配合中脘穴针刺治疗阿尔茨海默病临床研究  

Clinical Study on Treatment of Alzheimer's Disease by Needling"Kongque Kaiping"Group Points and CV12

作　　者：李全[1,2] 邢春玥[1] 王新宇 潘婷婷 孙晓伟[1,2] LI Quan;XING Chunyue;WANG Xinyu;PAN Tingting;SUN Xiaowei(Heilongjiang University of Chinese Medicine, Harbin 150040, China;The First Affiliated Hospital of Heilongjiang University of Chinese Medicine, Harbin 150040,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040 [2]黑龙江中医药大学附属第一医院,黑龙江哈尔滨150040

出　　处：《针灸临床杂志》2020年第8期22-27,共6页Journal of Clinical Acupuncture and Moxibustion

基　　金：黑龙江中医药大学校基金杰出培育基金,编号:2019JC05;黑龙江中医药大学优秀创新人才支持计划-优秀青年学术带头人支持项目,编号:2018RCD11。

摘　　要：目的:观察“孔雀开屏”组穴配合中脘穴对阿尔茨海默病(AD)患者认知能力及生活自理能力的临床疗效。方法:将60例患者随机分为治疗组和对照组,各30例。两组患者在维持原有基础疾病的治疗上,给予胆碱酯酶抑制剂盐酸多奈哌齐5 mg,日1次睡前口服,并配合健康指导。治疗组予“孔雀开屏”组穴配合中脘穴针刺治疗,对照组予常规针刺治疗。两组均4周为一疗程,共治疗2个疗程。观察治疗前、治疗4周、治疗8周及治疗结束后2个月的简易精神状态检查量表(MMSE)、阿尔茨海默病认知分量表(ADAS-cog)、日常生活能力量表(ADL)评分及经颅多普勒(TCD)检测的脑血管平均血流速度(Vm)的变化情况。结果:治疗组总有效率为82.1%(23/28),对照组总有效率为72.4%(21/29),两组比较差异具有统计学意义(P<0.05)。两组患者治疗4周后,治疗组与对照组的MMSE评分、ADAS-cog评分、ADL评分及脑血管平均血流速度均较治疗前有所改善,但差异无统计学意义(P>0.05)。治疗8周后治疗组和对照组MMSE评分较治疗前增高,ADAS-cog评分及ADL评分较前降低,各组脑血管的Vm均较前增快,差异具有统计学意义(P<0.05)。治疗结束后2个月随访,治疗组患者的MMSE评分较治疗8周后仍有增长,ADAS-cog评分及ADL评分较治疗8周后仍有降低,差异具有统计学意义(P<0.05);对照组患者的MMSE评分、ADAS-cog评分及ADL评分较治疗8周后无明显变化,差异无统计学意义(P>0.05)。结论:应用“孔雀开屏”组穴配合中脘穴针刺疗法可延缓痴呆进程,对提高AD患者的认知功能、改善患者的日常生活自理能力及脑血管平均血流速度较对照组更有优势,且其远期疗效优于对照组。Objective:To observe the clinical effect of"Kongque Kaiping"needling combined with needling Zhongwan(CV12)on Alzheimer's disease(AD)patients’cognitive ability and life self-care ability.Methods:60 AD patients were randomly divided into the treatment group and the control group,with 30 cases in each group.The two groups of patients were given the cholinesterase inhibitor Donepezil Hydrochloride(5 mg)on the treatment basis of maintaining the original underlying disease,once a day before bedtime;on which basis,the treatment group was treated with"Kongque Kaiping"needling combined with needling CV12,whereas the control group was treated with conventional acupuncture.Four weeks was taken as one course of treatment,and the two groups were treated for two courses.The scores of Mini-Mental State Examination Scale(MMSE),Alzheimer's Disease Cognitive Scale(ADAS-cog)and Activities of Daily Living(ADL)were observed,and the average blood flow velocity(Vm)of cerebral blood vessels were detected by transcranial Doppler(TCD)before the treatment,after 4 weeks of treatment,after 8 weeks of treatment and 2 months after the treatment in the two groups.Results:The total effective rate of the treatment group was 82.1%(23/28),which was significantly higher than 72.4%(21/29)of the control group(P<0.05).After 4 weeks of treatment,the scores of MMSE,ADAS-cog and ADL,as well as the average cerebral blood flow velocity were improved in the two groups;of which there were no statistical differences between the two groups(P>0.05).After 8 weeks of treatment,the MMSE scores were higher and the scores of ADAS-cog and ADL were lower,the Vm of cerebral blood vessels became faster in the two groups compared to those before the treatment(P<0.05).During the follow-up of 2 months after the treatment,the MMSE score in the treatment group was still higher,the ADAS-cog score and ADL score were still lower than those after 8 weeks of the treatment(P<0.05).The MMSE score,ADAS-cog score and ADL score of the control group were not significantly changed afte

关 键 词：阿尔茨海默病 针刺 多奈哌齐 简易精神状态检查量表 日常生活能力量表 经颅多普勒 

分 类 号：R246.6[医药卫生—针灸推拿学]