ⅠA期肺腺癌气道播散临床病理因素分析  

Analysis of clinicopathological factors of spread through air spaces in stage ⅠA lung adenocarcinoma

作　　者：陈亮 王喆歆[1] 姚烽[1] CHEN Liang;WANG Zhe-xin;YAO Feng(Department of Thoracic Surgery,Shanghai Chest Hospital,Shanghai Jiao Tong University,Shanghai 200030,China)

机构地区：[1]上海交通大学附属胸科医院胸外科,上海200030

出　　处：《上海交通大学学报（医学版）》2020年第7期957-961,共5页Journal of Shanghai Jiao tong University:Medical Science

摘　　要：目的·研究ⅠA期肺腺癌发生气道播散(spread through air space,STAS)的临床及病理危险因素。方法·回顾性收集2018年1月—2019年10月于上海交通大学附属胸科医院接受肺部手术且经术后病理诊断为ⅠA期肺腺癌患者的临床资料。根据是否存在STAS将其分为有STAS组和无STAS组。采用单因素分析及二分类Logistic回归分析对ⅠA期肺腺癌发生STAS的危险因素进行研究。结果·共计纳入ⅠA期肺腺癌患者1365例,其中无STAS组患者1312例,有STAS组患者53例。单因素分析显示,2组患者在性别、肺腺癌主要亚型上差异具有统计学意义(均P=0.000),而T分期的差异则无统计学意义。二分类Logistic回归分析显示,男性及非伏壁型为主的腺癌亚型是独立危险因素。结论·对于ⅠA期肺腺癌的治疗,尤其包含微乳头亚型,临床医师应注意STAS发生的可能。Objective·To investigate the clinicopathological risk factors of spread through air space(STAS)in stage ⅠA lung adenocarcinoma.Methods·The clinical data of patients with stage ⅠA lung adenocarcinoma who underwent lung surgery in Shanghai Chest Hospital,Shanghai Jiao Tong University from Jan.2018 to Oct.2019 were retrospectively collected.According to whether STAS happened,the patients were divided into STAS group and non-STAS group.Univariate analysis and binary Logistic regression analysis were used to analyze the risk factors of STAS in stage ⅠA lung adenocarcinoma between the two groups.Results·A total of 1365 patients with stageⅠA lung adenocarcinoma were included,including 1312 patients without STAS and 53 patients with STAS.Univariate analysis showed that there were significant differences in gender and major subtypes of lung adenocarcinoma between the two groups(both P=0.000),but there was no significant difference in T stage between the two groups.Binary Logistic regression analysis showed that male and non-lepidic subtypes were independent risk factors.Conclusion·For the treatment of stage ⅠA lung adenocarcinoma,especially those with micropapillary subtype,the clinicians should pay attention to the possibility of STAS.

关 键 词：肺腺癌 微乳头 气道播散 

分 类 号：R655.3[医药卫生—外科学]