影像组学在^18F-FDG PET/CT研究进展及临床应用  

Research progresses and clinical application of radiomics in 18^F-FDG PET/CT

作　　者：高超[1,2] 孙莹莹 孙夕林[1,2] GAO Chao;SUN Yingying;SUN Xilin(TOF-PET/CT/MR Center,the Fourth Affiliated Hospital of Harbin Medical University,Harbin 150028,China;Molecular Imaging Research Center,Harbin Medical University,Harbin 150028,China)

机构地区：[1]哈尔滨医科大学附属第四医院TOF-PET/CT/MR中心,黑龙江哈尔滨150028 [2]哈尔滨医科大学分子影像研究中心,黑龙江哈尔滨150028

出　　处：《中国医学影像技术》2020年第8期1239-1242,共4页Chinese Journal of Medical Imaging Technology

基　　金：国家自然科学基金(81627901);国家重点基础研究发展计划(2015CB931800)。

摘　　要：近年来,PET临床应用发展迅速,借助^18F-FDG或多种类型在体放射性分子示踪剂,可无创地从功能及分子水平提供活体内肿瘤信息。影像组学是基于计算机学习的医学影像分析方法。微观分子水平上的基因或蛋白质变化可在宏观影像图片上有所体现。深度挖掘影像特征,可反映人体组织、细胞和基因水平变化,预测和评估肿瘤异质性。本文聚焦于影像组学流程和研究重点、难点及18F-FDG PET影像组学临床应用,对目前^18F-FDG PET影像组学预测肿瘤分子分型相关进展进行综述。In recent years,clinical applications of PET developed rapidly.With^18F-FDG and other types in vivo radioactive molecular tracers,PET can provide tumor information in vivo from the functional and molecular levels.Radiomics is a medical imaging analysis approach based on computer learning.In the microscopic molecular level,changes of gene or protein can be reflected in macroscopic image pictures.Through deep mining of image features,the changes of human tissue,cells and genes can be reflected for predicting and evaluating the heterogeneity of tumors.The process of imaging omics and the key and difficult points of research and clinical applications of^18F-FDG PET imaging omics were focused,and the current progresses of^18F-FDG PET in imaging histology for predicting tumor molecular subtypes were reviewed in this article.

关 键 词：氟脱氧葡萄糖F18 正电子发射断层显像 体层摄影术 X线计算机 影像组学 

分 类 号：R445[医药卫生—影像医学与核医学] R817.84[医药卫生—诊断学]