Ofloxacin loaded M0S2 nanoflakes for synergistic mild-temperature photothermal/antibiotic therapy with reduced drug resistance of bacteria  

作　　者：Yue Huang Qiang Gao Xu Li Yifan Gao Haijie Han Qiao Jin Ke Yao Jian Ji 

机构地区：[1]MOE Key Laboratory of Macromolecule Synthesis and Functionalization of Ministry of Education,Department of Polymer Science and Engineering,Zhejiang University,Hangzhou 310027,China [2]Eye Center,the 2nd Affiliated Hospital,School of Medicine,Zhejiang University,88 JiefangRoad,Hangzhou 310009,China

出　　处：《Nano Research》2020年第9期2340-2350,共11页纳米研究（英文版）

基　　金：Financial support from the National Natural Science Foundation of China(No.21774110);Fundamental Research Funds for the Central Universities(Nos.2019QNA4063 and 2019XZZX005-1-03)is gratefully acknowledged.

摘　　要：Antibiotic resistance is an increasingly serious threat to global public health, which can lead to the decrease of the effectiveness ofantibiotics. The combination therapy of antibiotic and mild temperature photothermal therapy (PTT) is adopted to address this issue inthis work. An antibiotic-loaded nanoplatform is fabricated based on two-dimensional (2D) molybdenum disulfide (M0S2) nanoflakesas effective near-infrared (NIR) photothermal agent. The M0S2 nanoflakes is modified with positively charged quaternized chitosan(QCS) to improve the dispersion stability and enhance the interaction between M0S2 nanoflakes and bacterial membrane. TheQCS modified M0S2 nanoflakes (QCS-M0S2) is expected to adhere onto the membrane of methicillin-resistant Staphylococcusaureus (MRSA) and depolarize the bacterial membrane by local hyperthermia under NIR irradiation. A first-line antibiotic, ofloxacin(OFLX), can be loaded onto QCS-M0S2 by π-π stacking and hydrophobic interaction. Due to the combined antibiotic-photothermaltherapy, superior bactericidal ability was achieved at mild temperature (45℃) and low antibiotic concentration. Such synergisticmild-temperature photothermal/antibiotic therapy can not only avoid the damage to neighboring tissue by PTT, but also reduce thedevelopment of drug resistance, providing an innovative way for the treatment of bacterial infections.

关 键 词：antibacterial nanoplatform combination therapy photothermal therapy molybdenum disulfide antibiotic resistance 

分 类 号：TB383[一般工业技术—材料科学与工程]