Molecular recognition and homochirality preservation of guanine tetrads in the presence of melamine  

作　　者：Yanghan Chen Chong Chen Pengcheng Ding Guoqiang Shi Ye Sun Lev N.Kantorovich Flemming Besenbacher Miao Yu 

机构地区：[1]Condensed Matter Science and Technology Institute,School of Instrumentation Science and Engineerinz Harbin Institute of Technologry,Harbin 150001,China [2]State Key Laboratory of Urban Water Resource and Environment,School of Chemistry and Chemical Engineering,Harbin Institute oj Technology,Harbin 150001,China [3]Department of Physics,Kings College London,London WC2R 2LS,UK [4]Interdisciplinary Nanoscience Center,Aarhus University,Aarhus 8000,Denmark

出　　处：《Nano Research》2020年第9期2427-2430,共4页纳米研究（英文版）

基　　金：This work was financially supported by the National Natural Science Foundation of China(Nos.21473045 and 51772066);State Key Laboratory of Urban Water Resource and Environment,Harbin Institute of Technology(No.2018DX04).

摘　　要：Molecular recognition between nucleobases plays a crucial role in all kinds of biological processes.However,real-space investigation of the recognition capability of nucleobases in the presence of interfering compounds remains unexplored.Herein,based on the combination of scanning tunneling microscopy imaging and density functional theory modeling,we report the impact of the presence of melamine(M)on the formation and chirality of guanine(G)-tetrads on Au(111).Although M can interact with G by double hydrogen bonding,the Hoogsteen base pairing of G is not compromised,forming identical individual G-tetrads as would have happened without the presence of M.G-tetrads coexist with M on the surface not only in separate domains,but also within the mixture network of G-tetrads and M-dimers.Although the adsorption orientation of G-tetrads in the mixture network diversifies into two distinct angles,all G-tetrads in the network keep the same chirality,emphasizing the high preference of homochirality in such biochemical systems.

关 键 词：molecular recognition guanine-tetrad base pairing homcxjhirality biochemical synthesis 

分 类 号：Q78[生物学—分子生物学]