中老年2型糖尿病患者骨骼肌含量的影响因素研究  

Influencing Factors of Skeletal Muscle Mass in Middle Aged and Elderly Patients with Type 2 Diabetes Mellitus

作　　者：戚艳艳[1] 郑欣[1] 佟艳铭[1] 毕丽娜[1] 胡苏 赵丹 Qi Yanyan;Zheng Xin;Tong Yanming(Department of Endocrinology,Beijing Bo′ai Hospital,China Rehabilitation Research Center,School of Rehabilitation Medicine,Capital Medical University,China Rehabilitation Science Institute,Beijing 100068,China)

机构地区：[1]中国康复研究中心北京博爱医院内分泌科、首都医科大学附属康复医学院、中国康复科学所,100068

出　　处：《医学研究杂志》2020年第9期112-115,共4页Journal of Medical Research

基　　金：中央级公益性科研院所基本科研业务费专项资金资助项目(2014CZ-27)。

摘　　要：目的研究中老年2型糖尿病患者(T2DM)骨骼肌含量的相关影响因素。方法选取2018年12月~2019年10月中国康复研究中心北京博爱医院内分泌科收治的中老年T2DM患者共324例,根据亚洲肌少症诊断标准分为肌量减少组(176例)和肌量正常组(148例),测量身体成分和相关临床指标,采用相关性分析和多元线性回归分析骨骼肌含量的影响因素。结果中老年T2DM患者肌量减少组年龄高于肌量正常组(P=0.000),肌量减少组体重指数(body mass index,BMI)、四肢骨骼肌质量指数(appendicular skeletal muscle mass index,ASMI)、全身骨骼肌含量、上肢和下肢骨骼肌含量、体脂百分比低于肌量正常组(P<0.05)。Pearson相关分析显示,ASMI与年龄、病程、体脂百分比、促甲状腺激素(TSH)呈负相关(P<0.05),与BMI、骨矿物质含量(bone mineral content,BMC)呈正相关(P<0.01)。多元线性逐步回归分析显示BMI、BMC、体脂百分比对中老年T2DM患者ASMI影响比较,差异有统计学意义。结论BMI、BMC、体脂百分比是中老年T2DM患者骨骼肌含量的重要影响因素。Objective To investigate the related influencing factors of skeletal muscle mass in middle aged and elderly patients with T2DM.Methods A total of 324 middle aged and elderly patients with T2DM treated in the Department of Endocrinology,China Rehabilitation Research Center from December 2018 to October 2019 were selected.The subjects were divided into the muscle mass loss group(176 cases)and normal muscle mass group(148 cases)according to the Asian Working Group for Sarcopenia.The body composition and related clinical indicators were measured,and the influencing factors of skeletal muscle mass were analyzed by correlation analysis and multiple linear regression.Results The normal muscle mass group was older than the muscle mass loss group(P=0.000).The body mass index(BMI),appendicular skeletal muscle mass index(ASMI),total skeletal muscle mass,upper limb skeletal muscle mass,lower limb skeletal muscle mass,and percentage of body fat in normal muscle mass group were lower than those in the normal muscle mass group(P<0.05).Pearson correlation analysis showed that ASMI was negatively correlated with age,course of disease,percentage of body fat,and thyroid stimulating hormone(TSH)(P<0.05),and was positively correlated with BMI and bone mineral content(BMC)(P<0.01).Multiple linear stepwise regression analysis showed that BMI,BMC,and percentage of body fat had statistically significant effects on ASMI in middle aged and elderly patients with T2DM.Conclusion BMI,BMC and percentage of body fat are important influencing factors of skeletal muscle mass in middle aged and elderly patients with T2DM.

关 键 词：骨骼肌 2型糖尿病 体脂百分比 骨矿含量 

分 类 号：R587.1[医药卫生—内分泌]