基于层次分析法的正交试验优选跌打酒的渗漉提取工艺  

Optimization of Percolation Extraction Process of Dieda Jiu(跌打酒)Based on Analytic Hierarchy Process and Orthogonal Experiment

作　　者：蓝晓庆 陆兰娟 黄敏[3] 韦瑀龙[3] LAN Xiao-qing;LU Lan-juan;HUANG Min;WEI Yu-long(Guangxi Institute of Product Quality Inspection,Nanning Guangxi 530001,China;Guangxi Minsheng Zhongjianlian Detection Co.,Ltd.,Nanning Guangxi 530001,China;Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine,Nanning Guangxi 530001,China)

机构地区：[1]广西产品质量检验研究院,广西南宁530001 [2]广西民生中检联检测有限公司,广西南宁530001 [3]广西中医药大学附属瑞康医院,广西南宁530001

出　　处：《中医药导报》2020年第12期32-35,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：广西高校中青年教师基础能力提升项目(J16026)。

摘　　要：目的:优选跌打酒的渗漉提取工艺,为该制剂的工业化生产工艺改进提供参考。方法:以马钱子碱、士的宁、总皂苷和含固量为综合评价指标,乙醇体积分数、用量、渗漉速度、浸渍时长为考察因素,采用层次分析法结合L9(34)正交试验优选跌打酒的渗漉提取工艺。结果:最佳提取工艺为加7倍量75%乙醇浸渍12 h后以1.5 mL/(min·kg)流速渗漉。结论:优选的工艺提取效率高、重复性好,适用于工业化生产。Objective: To optimize the percolation extraction process of Dieda Jiu, and to provide a reference for the improvement of the industrialized production process of the preparation. Methods: The content of brucine, strychnine, total saponins and solid-containing content as comprehensive evaluation indexs, and ethanol volume fraction, dosage, percolation speed, and immersion time as investigating factors, the percolation extraction process of Dieda Jiu was optimized by using the analytic hierarchy process(AHP) combined with L9(34) orthogonal test. Results: The optimal extraction process was as follows: 7 times of 75% ethanol was added and soaked for 12 h, then percolated at the flow rate of 1.5 mL/(min·kg). Conclusion: The optimized process has high extraction efficiency and good repeatability, and is suitable for industrial production.

关 键 词：跌打酒 层次分析法 正交试验 马钱子碱 士的宁 总皂苷 提取工艺 

分 类 号：R284.2[医药卫生—中药学]