中医药治疗食管癌的抗凋亡靶点机制研究进展  

Research Progress of Anti-Apoptosis Target Mechanism of Chinese Medicine in the Treatment of Esophageal Cancer

作　　者：车琳琳[1] 李想[1] 曹明明[1] 张贺[1] 宋业旭[1] 李冀[1] CHE Lin-lin;LI Xiang;CAO Ming-ming;ZHANG He;SONG Ye-xu;LI Ji(Heilongjiang University of Chinese Medicine,Harbin Heilongjiang 150040,China)

机构地区：[1]黑龙江中医药大学,黑龙江哈尔滨150040

出　　处：《中医药导报》2020年第12期157-160,共4页Guiding Journal of Traditional Chinese Medicine and Pharmacy

基　　金：李冀全国名老中医药专家传承工作室项目(2014)。

摘　　要：总结了食管癌的中医药研究进展,认为中医药治疗食管癌时抗凋亡具有多靶点性,更有其独特优势。中医药治疗食管癌时抗凋亡的途径包括外源性死亡受体途径、内源性线粒体途径,但不限于此。利用不同的单体和中药复方,可以调节Bcl-2/Bax的比值、Caspase蛋白酶、活性氧、Fas和p53、NF-κB通路的表达,阻断细胞周期进程,抑制自噬等。The research progress of Chinese Medicine in esophageal cancer is reviewed. It is concluded that the anti-apoptosis of Chinese Medicine in the treatment of esophageal cancer has multiple targets and unique advantages. The anti-apoptotic pathways of Chinese Medicine in the treatment of esophageal cancer include exogenous death receptor pathway, endogenous mitochondrial pathway, but not limited to this. According to different monomers and Chinese Medicine compound, it can regulate the ratio of Bcl-2/Bax, Caspase protease,active oxygen, Fas and p53, and NF-κB pathway expression, block the process of cell cycle and inhibit autophagy and so on.

关 键 词：中医药 食管癌 抗凋亡途径 综述 

分 类 号：R273[医药卫生—中西医结合]