新型冠状病毒肺炎肝损伤特征分析  

Characteristics of hepatic damage in patients with coronavirus disease 2019

作　　者：孔令喜 田文广[1] 万克强[1] 魏晓宇[1] 周夏袷 Kong Lingxi;Tian Wenguang;Wan Keqiang;Wei Xiaoyu;Zhou Xiaqia(Department of Infectious Diseases,Yongchium Hospital of Chongqing Medical University)

机构地区：[1]重庆医科大学附属永川医院感染科,重庆402160

出　　处：《重庆医科大学学报》2020年第7期995-997,共3页Journal of Chongqing Medical University

摘　　要：目的:分析新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)患者肝功能损伤的特征。方法:回顾性分析2020年1月21日至2月20日重庆医科大学附属永川医院收治确诊的90例COVID-19患者临床资料,总结分析COVID-19发生肝功能损伤的原因及特征。结果:90例确诊患者共33例出现肝功能损伤,肝功能损伤率为36.7%,发生肝功能损伤的平均时间为(9.0±6.1)d;轻症组肝功能损伤率为32.5%,重症组肝功能损伤率为61.5%,差异具有统计学意义(P<0.05);轻症组体质指数(body mass index,BMI)为(24.3±2.3)kg/m^2,重症组BMI为(22.7±3.6)kg/m^2,差异具有统计学意义(P<0.05);肝功能损伤与性别、年龄、肝脏基础疾病无统计学差异(P>0.05)。结论:出现肝功能损伤以轻度损伤为主,与原发疾病、疾病严重程度、BMI有关,药物、肝脏基础疾病可能起了一定促进作用。随着原发病好转,肝损伤逐渐好转,预后较好。Objective:To analyze the characteristics of hepatic damage in patients with coronavirus disease 2019(COVID-19).Methods:Clinical data of 90 patients with COVID-19 from January 21,2020 to February 20,2020 were analyzed retrospectively.The causes and characteristics of hepatic damage in COVID-19 were analyzed and summarized.Results:Among 90 patients,33 had hepatic damage,with the rate of 36.7%.The average time of hepatic damage was 9.0±6.1 days.The rate of hepatic damage in the mild group was 32.5%and in the severe group was 61.5%,showing a statistical difference(P<0.05).BMI in the mild group was(24.3±2.3)kg/m^2 and in the severe group was(22.7±3.6)kg/m^2,with significant difference(P<0.05).There was no statistical difference between hepatic damage and gender,age and the underlying liver disease(P>0.05).Conclusion:The hepatic damage in COVID-19 patients is mainly mild,which is related to the primary disease,the severity of the disease and BMI,The drug and the underlying liver disease may play a certain promoting role.With the improvement of the primary disease,the liver injury is gradually improved,with good prognosis.

关 键 词：新型冠状病毒 新型冠状病毒肺炎 肝功能损伤 

分 类 号：R511[医药卫生—内科学]