匹伐他汀联合多廿烷醇治疗高龄男性冠心病患者的疗效及安全性评估  

Efficacy and safety assessment of pitavastatin with policosanol in the treatment of very elderly male patients with coronary artery disease

作　　者：刘立新[1] 武云涛 陈艳梅 Liu Lixin;Wu Yuntao;Chen Yanmei(Fourth Department of Geriatric Cardiovascular Medicine,Seventh Medical Center of Chinese PLA General Hospital,Beijing 100700,China;不详)

机构地区：[1]解放军总医院第七医学中心老年医学科,北京100700

出　　处：《中国循证心血管医学杂志》2020年第8期975-978,983,共5页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的探讨匹伐他汀联合多廿烷醇治疗高龄男性冠状动脉粥样硬化性心脏病(冠心病)患者的多效性和安全性。方法选取2018年5月~2019年12月于解放军总医院第七医学中心收治的90例80岁以上男性冠心病患者,根据用药情况分为对照组(40例),研究组(50例)。对照组接受匹伐他汀2 mg,口服,1/晚治疗,研究组接受匹伐他汀钙2 mg+多廿烷醇10 mg,口服,1/晚治疗。回顾性分析治疗前及治疗12周后的血压、总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、载脂蛋白A(apoA)、载脂蛋白(apoB)、脂蛋白(a)[Lp(a)]、谷丙转氨酶(ALT)、谷草转氨酶(AST)、肌酸激酶(CK)、空腹血糖、血小板计数变化情况,并记录皮疹、消化道或肌肉等不良反应。结果治疗12周后,研究组的TC、LDL-C、apoB水平显著低于治疗前(P<0.05);研究组的TC、LDL-C水平显著低于对照组(P<0.05)。两组未观察到明显的不良反应,ALT、AST升高或CK升高发生比例均无明显差异,亦未发现血压、空腹血糖及血小板计数变化存在显著性差异(P>0.05)。结论匹伐他汀联合多廿烷醇能够进一步改善高龄冠心病患者的血脂水平,并且安全性相对良好。Objective To evaluate the clinical multi effects and safety of pitavastatin plus cuba policosanol treatment for coronary artery disease in very elderly male patients.Methods Ninety male patients over 80 years old with coronary artery disease in seventh medical center of Chinese PLA general hospital from May 2018 to December 2019 were divided into control group(n=40)and combined treatment group(n=50).Patients in control group were treated with pitavastatin(2mg per day)for 12 weeks,while those in combined treatment group were treated with policosanol(10 mg per day)and pitavastatin(2mg per day).The blood pressure(BP),total cholesterol(TC),triglycerides(TG),low density lipoprotein cholesterol(LDL-C),high density lipoprotein cholesterol(HDL-C),apolipoprotein A(apoA),apolipoprotein(apoB),Lipoprotein(a)[Lp(a)],alanine aminotransferase(ALT),aspartate aminotransferase(AST),creatine kinase(CK),fasting blood glucose,platelet count(PLT)were measured pre-and post-intervention and then compared.Meanwhile,the adverse reactions were also observed.Results The serum levels of TC,LDL-C,apoB were significantly reduced in combined treatment group at week 12 compared with week 0(P<0.05).Additionally,blood TC,LDL-C levels in combined treatment group were significantly lower than those in control group at week 12(P<0.05).There was no significant difference in the BP,and blood FBG,PLT levels between two groups at week 0 and week 12(P>0.05).No obvious adverse reactions were found in the two groups,and there were no significant differences in the incidence of elevated ALT,AST or CK between two groups during intervention.Conclusions Pitavastatin combined with policosanol can further improve lipid parameters,and has a good safety in very elderly patients.

关 键 词：匹伐他汀 多廿烷醇 血脂 冠心病 老年 

分 类 号：R541.4[医药卫生—心血管疾病]