血清LncRNA MIR155HG对冠心病患者PCI后冠状动脉再狭窄的预测价值  

The predictive value of serum LncRNAMIR155HG in coronary artery restenosis in patients with coronary heart disease after PCI

作　　者：张浩[1] 徐寅 郭明凯 马良[1] Zhang Hao;Xu Yin;Guo Mingkai;Ma Liang(Department of cardiovascular,Yellow River Sanmenxia hospital,Sanmenxia 472000,China;不详)

机构地区：[1]黄河三门峡医院心血管内科,三门峡472000 [2]黄河三门峡医院理疗科,三门峡472000

出　　处：《中国循证心血管医学杂志》2020年第8期984-987,共4页Chinese Journal of Evidence-Based Cardiovascular Medicine

摘　　要：目的探讨血清长链非编码RNA MIR155宿主基因(LncRNA MIR155HG)对冠状动脉粥样硬化性心脏病(冠心病)患者经皮冠状动脉介入术(PCI)后冠状动脉(冠脉)再狭窄的预测价值。方法选取2015年4月~2017年4月于黄河三门峡医院心血管内科接受PCI的冠心病患者155例,根据术后6个月内扩张部位发生再狭窄情况分为再狭窄组(65例)和未狭窄组(90例),另选取105例同期健康体检者作为对照组。实时荧光定量PCR(qRT-PCR)法检测受试者血清中LncRNA MIR155HG表达水平;Pearson法分析LncRNA MIR155HG表达水平与Gensini评分的关系;受试者工作特征曲线(ROC)评估LncRNA MIR155HG表达水平对冠心病患者PCI后冠脉再狭窄的预测价值。结果与对照组相比,再狭窄组和未狭窄组患者收缩压(SBP)、舒张压(DBP)、体质指数(BMI)、左室射血分数(LVEF)、左室舒张末期内径(LVEDD)、左心室收缩末直径(LVESD)有显著差异(P<0.05);与未狭窄组相比,再狭窄组患者SBP、DBP、BMI、LVEF、LVEDD、LVESD也有显著差异(P<0.05)。再狭窄组患者血清中LncRNA MIR155HG表达水平显著高于未狭窄组和对照组(P<0.05);未狭窄组患者血清中LncRNA MIR155HG表达水平显著高于对照组(P<0.05)。血清LncRNA MIR155HG表达水平与Gensini评分呈正相关(r=0.542,P<0.05)。LncRNA MIR155HG预测冠心病患者PCI后冠脉再狭窄的ROC曲线下面积为0.881(95%CI:0.804~0.959),截断值为6.550,敏感度为80.0%,特异性为87.5%。结论与未狭窄组和对照组相比,再狭窄组患者血清LncRNA MIR155HG表达水平明显升高,与Gensini评分呈正相关,对冠心病患者PCI后冠脉再狭窄具有一定诊断价值。Objective To detect the value of serum long non-coding RNA MIR155 host gene(LncRNAMIR155HG)in predicting coronary restenosis after percutaneous coronary intervention(PCI)in patients with coronary heart disease.Methods From April 2015 to April 2017,155 patients with coronary heart disease who underwent PCI were selected and divided into restenosis group(65 cases)and non stenosis group(90 cases)according to the restenosis of the dilated area within 6 months after operation,and another 105 healthy persons at the same period were selected as the control group.The expression of LncRNAMIR155HG in serum was detected by realtime fluorescence quantitative PCR(qRT-PCR).Pearson method was used to analyze the relationship between the expression level of LncRNAMIR155HG and Gensini score,And receiver operating characteristic curve(ROC)was used to evaluate the predictive value of the expression level of LncRNAMIR155HG in patients with coronary artery restenosis after PCI.Results Compared with the control group,systolic blood pressure(SBP),diastolic blood pressure(DBP),body mass index(BMI),left ventricular ejection fraction(LVEF),left ventricular end-diastolic diameter(LVEDD).There is a significant difference in the left ventricular end-systolic diameter(LVESD)(P<0.05).Compared with the non-stenotic group,SBP,DBP,BMI,LVEF,LVEDD,and LVESD in the restenotic group also have significant differences(P<0.05).Serum LncRNA MIR155HG expression levels in the restenosis group were significantly higher than those in the non-stenosis group and the control group(P<0.05).Serum LncRNA MIR155HG expression levels in the non-stenosis group were significantly higher than the control group(P<0.05).Serum LncRNA MIR155HG expression level was positively correlated with Gensini score(r=0.542,P<0.05).LncRNA MIR155HG predicts the area under the ROC curve of coronary artery restenosis in patients with coronary heart disease after PCI is 0.881(95%CI:0.804~0.959),the cutoff value is 6.550,the sensitivity is 80.0%,and the specificity is 87.5%.Conclusions Comp

关 键 词：冠心病 经皮冠状动脉介入术 冠状动脉再狭窄 长链非编码RNA MIR155宿主基因 

分 类 号：R541.4[医药卫生—心血管疾病]