Continuous, homogeneous and rapid synthesis of 4-bromo-3-methylanisole in a modular microreaction system  

作　　者：Pei Xie Kai Wang Jian Deng Guangsheng Luo 

机构地区：[1]The State Key Laboratory of Chemical Engineering,Department of Chemical Engineering,Tsinghua University,Beijing 100084,China

出　　处：《Chinese Journal of Chemical Engineering》2020年第8期2092-2098,共7页中国化学工程学报（英文版）

基　　金：financial support from National Key R&D Program of China(2017YFB0307102);National Natural Science Foundation of China(21991100,21991104)。

摘　　要：4-Bromo-3-methylanisole is mainly used to synthesize black fluorane dye(2-anilino-3-methyl-6-dibutylaminofluorane, ODB-2), which is one of the most important heat and pressure-sensitive dyes in the manufacture of thermal papers. Compared to the industrial heterogeneous batch process, a continuous homogeneous bromination technology in a modular microreaction system has been developed, and 4-bromo-3-methylanisole has been successfully prepared through high-selective mono-bromination of 3-methylanisole with Br2 solution in CHCl3. In optimal conditions, the content of bis-brominated byproducts can be controlled less than 0.5%,which is superior to the industrial standard with 99.5% 3-methylanisole conversion at very short residence time and mild reaction temperature.

关 键 词：4-bromo-3-methylanisole BROMINATION continuous synthesis modular microreaction system mixing enhancement 

分 类 号：TQ610.1[化学工程—精细化工]