Long-time remission of epstein-barr virus associated hemophagocytic lymphohistiocytosis by interferon-α treatment  

作　　者：Jie Huang Chen-Lu Yang Ting Niu 

机构地区：[1]Department of Hematology and Hematological Research Laboratory,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China

出　　处：《Chinese Medical Journal》2020年第16期2007-2008,共2页中华医学杂志（英文版）

摘　　要：To the Editor:A 59-year-old Chinese woman was admitted for fatigue and fever for 1 month.She was diagnosed with chronic active Epstein-Barr virus(CAEBV)infection 3 years ago due to intermittent fever and documented Epstein-Barr virus positive serology.On physical examination,her spleen,liver,and superficial lymph nodes were not palpable.There was no sign of pulmonary infection.Initial laboratory tests were as follows:white blood cell count 0.92×10^9/L,hemoglobin 66 g/L,platelet count 15×10^9/L.Serum biochemistry:alanine aminotransferase 44 U/L,aspartate transaminoferase 142 U/L,albumin 26.7 g/L,triglyceride 3.02 mmol/L,and lactate dehydrogenase 1166 U/L.Coagulation indexes were as follows:prothrombin time 14.3 s,activated prothromboplastin time 65.9 s,thrombin time 32.2 s,D-dimer 18.35 mg/L,and fibrinogen 0.81 g/L.Serum ferritin level was significantly elevated to as high as 8500 ng/mL and serum soluble interleukin-2 receptor(sIL-2R)was 13,200 U/mL.On admission,her serum EBV-DNA load was 1.99×10^3 copies/mL.Computed tomography did not find any enlarged lymph nodes and the spleen and liver had a normal size.The bone marrow morphology and pathology revealed no sign of lymphoma but slight hemophagocytosis.

关 键 词：SPLEEN admitted SERUM 

分 类 号：R551.2[医药卫生—血液循环系统疾病]