Broad spectrum antibiotic-degrading metallo-β-lactamases are phylogenetically diverse  

作　　者：Marcelo Monteiro Pedroso David W.Waite Okke Melse Liam Wilson Natasa Mitic Ross P.McGeary Iris Antes Luke W.Guddat Philip Hugenholtz Gerhard Schenk 

机构地区：[1]School of Chemistry and Molecular Biosciences,The University of Queensland,St.Lucia,QLD,Brisbane 4072,Australia [2]Australian Centre for Ecogenomics,The University of Queensland,St.Lucia,QLD,Brisbane 4072,Australia [3]Center for Integrated Protein Science Munich at the TUM School of Life Sciences,Technische Universit(a)t München,85354 Freising,Germany [4]Department of Chemistry,Maynooth University,Maynooth,Co.Kildare,Ireland

出　　处：《Protein & Cell》2020年第8期613-617,共5页蛋白质与细胞（英文版）

摘　　要：Dear Editor, Antibiotic resistance has emerged as a major threat to global health;multi-drug resistant bacteria already kill more patients in the United States each year than HIV/AIDS, Parkinson's disease, emphysema and homicide combined (Laxminarayan et al., 2013).Among the most effective bacterial resistance mechanisms are β-lactamases, a family of enzymes that are divided into four distinct classes.Classes A, C and D (serine-β-lactamases, SBLs) use a catalytic site serine residue to initiate inactivation of the antibiotic, while Class B (metallo-β-lactamases, MBLs) relies on a Zn2+-activated hydroxide (Walsh et al., 2005;Bush and Jacoby,2010;Mitic et al., 2014;Lisa et al., 2017).Clinically relevant inhibitors of Class C and D SBLs are available and in use (e.g., clavulanic acid (CA), Drawz et al., 2010), but for MBLs the search for such inhibitors has remained challenging (McGeary et al., 2017).

关 键 词：HYDROXIDE metallo SPECTRUM 

分 类 号：R978.1[医药卫生—药品]