补肾调冲汤联合来曲唑治疗卵泡发育不良性不孕症疗效及对性激素的影响  

Curative effect of Bushen Tiaochong Decoction combined with letrozole on follicular maldevelopment infertility and its influence on sex hormones

作　　者：蔡云[1] 孙晔[1] 刘轶 CAI Yun;SUN Ye;LIU Yi(The First Affiliated Hospital of Xi’an Jiaotong University,Xi'an 710061,Shaanxi,China)

机构地区：[1]西安交通大学第一附属医院,陕西西安710061

出　　处：《现代中西医结合杂志》2020年第26期2890-2894,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察补肾调冲汤联合来曲唑对卵泡发育不良性不孕症患者卵泡及子宫内膜的改善作用及对性激素水平的影响。方法选取2016年2月—2019年1月西安交通大学第一附属医院收治的92例卵泡发育不良性不孕症患者,按随机数字表法将其分为来曲唑组和联合组,分别给予来曲唑、补肾调冲汤联合来曲唑治疗,均治疗3个月经周期。对比治疗后2组卵泡发育情况及子宫内膜改善情况,检测并对比治疗前后2组患者血清性激素水平[睾酮(T)、雌二醇(E 2)、促黄体生成素(LH)及卵泡刺激素(FSH)],统计2组临床疗效及治疗期间不良反应发生情况。结果联合组周期排卵率高于来曲唑组(P<0.05),小卵泡排卵率及无反应周期率低于来曲唑组(P均<0.05);2组优势卵泡发育率、黄素化卵泡不破裂综合征率比较差异均无统计学意义(P均>0.05);联合组排卵日子宫内膜厚度及A型内膜率均高于来曲唑组(P均<0.05),RI低于来曲唑组(P<0.05)。治疗后2组血清E 2、LH水平及联合组FSH水平均高于治疗前(P均<0.05),且联合组血清E 2、LH、FSH水平均高于来曲唑组(P均<0.05);治疗后联合组血清T水平低于治疗前(P<0.05),且低于来曲唑组(P<0.05);来曲唑组治疗前后血清T、FSH水平比较差异均无统计学意义(P均>0.05)。2组临床疗效等级分布比较差异有统计学意义(P<0.05),联合组临床总有效率高于来曲唑组(P<0.05);2组不良反应发生率比较差异无统计学意义(P>0.05)。结论补肾调冲汤联合来曲唑可有效促进卵泡发育不良性不孕症患者卵泡发育和排卵,改善子宫内膜容受性,调节性激素水平,临床疗效显著,且安全。Objective It is to observe the curative effect of Bushen Tiaochong Decoction combined with letrozole on the follicle and endometrium of patients with follicular maldevelopment infertility and the effect on the level of sex hormones.Methods A total of 92 patients with follicular maldevelopment infertility admitted to the First Affiliated Hospital of Xi’an Jiaotong University from February 2018 to January 2019 were divided into letrozole group and combination group by random number table.Letrozole group was treated with Letrozole,the combination group was treated with Bushen Tiaochong Decoction combined with letrozole,both groups were treated for 3 menstrual cycles.The development of follicles and the improvement of the endometrium in the two groups after treatment were compared,the serum sex hormone levels[testosterone(T),estradiol(E 2),luteinizing hormone(LH)and follicle stimulating hormone(FSH)]of the two groups were detected before and after treatment,the clinical efficacy of the 2 groups was evaluated and the occurrence of adverse reactions during treatment was recorded.Results The cycle ovulation rate of the combination group was higher than that of the letrozole group(all P<0.05),and the rate of small follicle ovulation and non-response cycles was lower than that of the letrozole group(all P<0.05);there was no significant difference in the development rate of dominant follicles and the rate of luteinized follicles non-rupture syndrome between the two groups(all P>0.05);the endometrial thickness and type A endometrial rate on the day of ovulation in the combination group were higher and the RI was lower than those in the letrozole group(all P<0.05).After treatment,the levels of serum E 2,LH in the two groups,and FSH in the combination group were higher than those before treatment(P<0.05),and the levels of serum E 2,LH,FSH in the combination group were higher than those in the letrozole group(P<0.05);the levels of serum T in the combination group after treatment was lower than that before treatment and in th

关 键 词：补肾调冲汤 来曲唑 卵泡发育不良 不孕症 子宫内膜 性激素 

分 类 号：R711.6[医药卫生—妇产科学]