补肺益气汤联合穴位贴敷对肺气亏虚型肺心病缓解期患者心肺功能及血管内皮功能的影响  

Effect of Bufei Yiqi Decoction combined with acupoint application on cardiopulmonary function and vascular endothelial function of patients with pulmonary heart disease in remission stage with syndrome of Lung Qi deficiency

作　　者：苏军[1] 张艳丽[1] SU Jun;ZHANG Yanli(Affiliated Hospital of Traditional Chinese Medicine,Xinjiang Medical University,Urumqi 830000,Xinjiang,China)

机构地区：[1]新疆医科大学附属中医医院,新疆乌鲁木齐830000

出　　处：《现代中西医结合杂志》2020年第26期2900-2904,共5页Modern Journal of Integrated Traditional Chinese and Western Medicine

摘　　要：目的观察补肺益气汤联合穴位贴敷对肺气亏虚型肺心病缓解期患者心肺功能及血管内皮功能的影响。方法选择2018年1月—2019年1月新疆医科大学附属中医医院诊治的肺气亏虚型肺心病缓解期患者126例,随机分为2组,对照组给予常规内科治疗,观察组在对照组基础上给予补肺益气汤联合穴位贴敷治疗,连续治疗4周。评估2组临床疗效,观察2组治疗前后心肺功能指标[心指数(CI)、第一秒用力呼气容积(FEV 1)/用力肺活量(FVC)、肺动脉压(PAP)]、血管内皮功能指标[一氧化氮(NO)、内皮素-1(ET-1)、血管性假血友病因子(vWF)],比较2组治疗期间不良反应发生情况,统计2组治疗前半年内及治疗后半年内急性加重发作次数。结果观察组治疗总有效率为92.1%(58/63),对照组为77.8%(49/63),观察组明显高于对照组(P<0.05)。与治疗前比较,2组治疗后PAP、ET-1、vWF水平及治疗后半年内急性期发作次数均明显降低(P均<0.05),CI、FEV 1/FVC、NO水平均明显升高(P均<0.05);与对照组比较,观察组治疗后上述各指标改善情况均明显优于对照组(P均<0.05)。2组治疗期间均未出现严重不良反应,不良反应发生率比较差异无统计学意义(P>0.05)。结论补肺益气汤联合穴位贴敷能够改善肺气亏虚型肺心病患者心肺功能和内皮功能,疗效确切。Objective It is to observe the effects of Bufei Yiqi Decoction combined with acupoint application on cardiopulmonary function and vascular endothelial function of patients with pulmonary heart disease in remission stage with syndrome of Lung Qi deficiency.Methods 126 patients with pulmonary heart disease in remission stage with syndrome of Lung Qi deficiency diagnosed and treated in the Affiliated Hospital of Traditional Chinese Medicine of Xinjiang Medical University from January 2018 to January 2019 were randomly divided into 2 groups.The control group was given conventional medical treatment,and the observation group was given Bufei Yiqi Decoction combined with acupoint application on the basis of the control group.Both groups were treated for 4 consecutive weeks.The clinical efficacy of the two groups was evaluated,the indicators of cardiopulmonary function[heart index(CI),forced expiratory volume per second(FEV 1)/forced vital capacity(FVC),pulmonary artery pressure(PAP)],vascular endothelial function indicators[nitric oxide(NO),endothelin-1(ET-1),von Willebrand factor(vWF)]before and after treatment were observed,the occurrence of adverse reactions during the treatment of the two groups were compared,and the the number of acute attacks within half a year before treatment and within half a year after treatment were calculated in the two groups.Results The total effective rate of treatment in the observation group was 92.1%(58/63),which was significantly higher than that 77.8%(49/63)in the control group(P<0.05).Compared with before treatment,the levels of PAP,ET-1,vWF and the number of acute attacks within half a year after treatment were significantly reduced(P<0.05),and the levels of CI,FEV 1/FVC,and NO were significantly increased in the two groups(P<0.05);compared with the control group,the improvement of the above indicators after treatment in the observation group was significantly better than that of the control group(P<0.05).No serious adverse reactions occurred in the two groups during treatment,and

关 键 词：肺心病 肺气亏虚型 补肺益气汤 穴位贴敷 心肺功能 血管内皮功能 

分 类 号：R541.5[医药卫生—心血管疾病]