药物转运体与代谢酶间的协作关系对肠肝药物处置的影响  

Effect of cooperation between transporters and metabolic enzymes on drug disposition by intestine and liver

作　　者：周燕 武新安[2] 邓毅[1,3] ZHOU Yan;WU Xin-an;DENG Yi(College of Pharmacy,Gansu College of Traditional Chinese Medicine,Lanzhou 730000,China;Department of Pharmacy,the 1st Hospital of Lanzhou University,Lanzhou 730000,China;Key Laboratory of Chemistry and Quality for Traditional Chinese Medicine of Gansu Province,Lanzhou 730000,China)

机构地区：[1]甘肃中医药大学药学院,甘肃兰州730000 [2]兰州大学第一医院药剂科,甘肃兰州730000 [3]甘肃省高校中(藏)药化学与质量研究省级重点实验室,甘肃兰州730000

出　　处：《药学学报》2020年第8期1762-1767,共6页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81603211,81960723)。

摘　　要：药物转运体和代谢酶均为机体处置药物的关键蛋白,且大部分药物的体内处置过程需要药物转运体和代谢酶的共同参与。近年来研究发现,药物转运体与代谢酶间存在协作关系,且药物转运体和代谢酶功能的变化可影响其协作处置药物的能力。因此,明晰药物转运体与代谢酶间的协作关系及规律,对于探究药物体内过程,药效和不良反应具有重要的意义。肠和肝是药物发生代谢的主要组织,且其分布有丰富的药物转运体和代谢酶,为此,本文综述了药物转运体和代谢酶间的协作关系对肠肝药物处置的影响。Drug transporters and metabolic enzymes are the key proteins in the disposition of drugs in the body.In recent years it has been found that there is a cooperative relationship between drug transporters and metabolizing enzymes.Functional changes in drug transporters or metabolizing enzyme can affect the ability to eliminate drugs.Therefore,it is important to clarify this cooperative relationship,which is directly related to the pharmacokinetics,pharmacodynamics and adverse effects of drugs.Intestine and liver are the main organs of drug metabolism.There are abundant drug transporters and metabolizing enzymes in the tissues.This paper reviews the influence of the cooperative relationship between drug transporters and metabolizing enzymes on drug disposition by intestine and liver.

关 键 词：药物转运体 代谢酶 肠道 肝脏 药物代谢动力学 

分 类 号：R969[医药卫生—药理学]