DNA条形码技术在中药全产业链的应用进展  

Application of DNA barcoding technology in the whole industrial chain of traditional Chinese medicine

作　　者：娄千 辛天怡 宋经元 LOU Qian;XIN Tian-yi;SONG Jing-yuan(Key Lab of Chinese Medicine Resources Conservation,State Administration of Traditional Chinese Medicine of the People's Republic of China,Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100193,China;Beijing University of Chinese Medicine,Beijing 102488,China;Engineering Research Center of Chinese Medicine Resource,Ministry of Education,Beijing 100193,China)

机构地区：[1]中国医学科学院、北京协和医学院药用植物研究所,国家中医药管理局中药资源保护重点研究室,北京100193 [2]北京中医药大学,北京102488 [3]中药资源教育部工程研究中心,北京100193

出　　处：《药学学报》2020年第8期1784-1791,共8页Acta Pharmaceutica Sinica

基　　金：国家自然科学基金资助项目(81874339);国家重大新药创制(2019ZX09201005-006-003)。

摘　　要：DNA条形码技术是通过一段标准的DNA序列进行生物物种鉴定的方法,在中药鉴定领域应用广泛,推动中药鉴定学的"文艺复兴"。中药全产业链包括上游中药种植、采收环节,中游中药材、中药饮片、中成药生产环节,以及下游中药流通与使用环节。DNA条形码技术以其准确、通用、客观的特点在中药全产业链各关键环节发挥作用。在产业链上游,对中药种子种苗、药用植物进行鉴定,保证源头正确;在产业链中游,对中药材、中药饮片以及中成药组方药进行鉴定,保证企业投料正确、临床用药安全;在产业链下游,参与构建中药溯源体系,实现中药"来源可查,去向可追",跟踪中药生产全过程,保障消费者权益,有助于中药监督管理。结合近年来具体研究实例,本文介绍DNA条形码技术在中药全产业链过程的应用,对促进中药产业现代化、推动中药国际化进程具有重要意义。DNA barcoding technology,a method of identifying biological species through a standard sequence,is widely used in the identification of traditional Chinese medicine(TCM),promoting the renaissance of TCM authentication discipline.The whole industrial chain of TCM includes three sections:the planting and collecting in the upstream chain,the production of TCM in the midstream chain and the circulation in the downstream chain.DNA barcoding technology,which possesses accurate,common,and objective advantages,plays an important role in the whole industrial chain of TCM.In the upstream,it is used to identify the seeds,seedlings and medicinal plants,ensuring the original source is correct.In the middle,it is used to identify Chinese medicinal materials,Chinese herbal slices and Chinese patent medicines,ensuring the materials of enterprises are correct and the clinical medication is safe.In the downstream,it participates in the establishment of traceability system for TCM,achieving the recording,inquiry and traceability of information.Therefore,DNA barcoding technology should help to control the whole production process,to protect the rights and interests of consumers and contribute to the supervision of TCM.Combined with some study cases in recent years,this paper introduces the application of DNA barcoding technology in the whole industrial chain of TCM,which is of great significance to promote the modernization of TCM industry and their internationalization.

关 键 词：DNA条形码技术 中药 全产业链 物种鉴定 溯源 

分 类 号：R931[医药卫生—生药学]