通塞脉片联合常规疗法对糖尿病足患者炎症因子及血液流变学的影响  

Effect of Tongsaimai tablets combined with conventional therapy on inflammatory factors and hemorheology in patients with diabetic foot

作　　者：闫少庆[1] 柳国斌[1] 朱忠强[2] 王丽翔[1] 杨晓[1] 胡啸明[1] YAN Shaoqing;LIU Guobin;ZHU Zhongqiang;WANG Lixiang;YANG Xiao;HU Xiaoming(Department of Chinese Medicine Vascular Surgery,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China;Endocrine Department,Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)

机构地区：[1]上海中医药大学附属曙光医院中医血管外科,上海201203 [2]上海中医药大学附属曙光医院内分泌科,上海201203

出　　处：《上海中医药杂志》2020年第9期65-67,72,共4页Shanghai Journal of Traditional Chinese Medicine

基　　金：上海市科委生物医药“三年”行动计划项目(16401902200)。

摘　　要：目的观察通塞脉片联合常规疗法对糖尿病足患者炎症因子及血液流变学的影响。方法将80例糖尿病足患者随机分为治疗组和对照组,每组40例。对照组予常规疗法(控制血糖、改善微循环、抗感染等综合治疗),治疗组在对照组治疗措施的基础上加用通塞脉片。两组疗程均为1个月,观察临床疗效,比较相关炎症指标及血液流变学指标的变化情况。结果①治疗组总有效率为87.5%,对照组总有效率为72.5%;治疗组临床疗效优于对照组(P<0.05)。②治疗前后组内比较,两组血清WBC、CRP、IL-6、TNF-α水平下降(P<0.05);组间治疗后比较,治疗组上述指标水平均低于对照组(P<0.05)。③治疗前后组内比较,治疗组全血高切黏度、全血低切黏度、血浆黏度、红细胞压积值及红细胞电泳速度差异有统计学意义(P<0.05),对照组上述指标差异无统计学意义(P>0.05);组间治疗后比较,治疗组全血高切黏度、全血低切黏度、血浆黏度、红细胞压积值低于对照组(P<0.05),红细胞电泳速度高于对照组(P<0.05)。结论与单纯采用常规疗法相比,加用通塞脉片治疗糖尿病足疗效满意,能更好地抑制机体炎症反应、改善微循环。Objective To observe the effect of Tongsaimai tablets combined with conventional therapy on inflammatory factors and hemorheology in patients with diabetic foot.Methods Eighty patients with diabetic foot were randomly divided into treatment group and control group,with 40 cases in each group.The control group was given conventional therapy(to control blood sugar,improve microcirculation and fight infection,etc.),while the treatment group was given Tongsaimai tablets besides the conventional therapy as in the control group.The course of treatment in both groups was one month.The clinical efficacy was observed and the changes of related inflammatory indexes and hemorheological indexes were compared.Results①The total effective rate of the treatment group was 87.5%while that of the control group was 72.5%.The clinical efficacy of the treatment group was better than that of the control group(P<0.05).②The levels of serum WBC,CRP,IL-6 and TNF-αin the two groups all decreased when compared before and after treatment(P<0.05).According to the comparison between two groups after treatment,the levels of WBC,CRP,IL-6 and TNF-αin the treatment group were lower than those in the control group(P<0.05).③There were significant differences in the levels of whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity,hematocrit and erythrocyte electrophoresis speed in the treatment group before and after treatment(P<0.05),but there was no significant difference in the levels of above indexes in the control group(P>0.05).After treatment,the levels of whole blood high shear viscosity,whole blood low shear viscosity,plasma viscosity and hematocrit in the treatment group were lower than those in the control group(P<0.05),and the erythrocyte electrophoresis speed was higher than that in the control group(P<0.05).Conclusion Compared with conventional therapy alone,the combined use of conventional therapy and Tongsaimai tablets can achieve more satisfactory effect on diabetic food treatment as Tongsaimai tablet

关 键 词：糖尿病足 炎症 中西医结合疗法 通塞脉片 血液流变学 微循环 

分 类 号：R587.2[医药卫生—内分泌]